eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | necrobiotic xanthogranuloma |
| Comorbidity | C0376545|hematologic malignancy |
| Sentences | 1 |
| PubMedID- 23271884 | hematologic malignancy in patients with necrobiotic xanthogranuloma in the form of multiple myeloma, leukemia, and lymphoma has been reported.1,2 the pathogenesis of necrobiotic xanthogranuloma is not well understood, but borrelia spirochetal infection has been proposed because organisms have been identified within the lesions.3 others have hypothesized that there is enhanced monocyte phagocytic activity leading to lipid accumulation and a subsequent giant cell inflammatory response in the skin.4 the relationship between the hematologic abnormalities and skin lesions is not currently understood. |
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