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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease muscular atrophy
Comorbidity C0006625|cachexia
Sentences 12
PubMedID- 22450024 In addition, asp and colleagues observed that chronic administration of rosiglitazone prevented muscle wasting associated with cancer cachexia in mice implanted with the colon-26 adenocarcinoma [39].
PubMedID- 22909172 During these pathological conditions commented on, muscle wasting leads to cachexia, a syndrome characterized by weight loss and profound metabolic abnormalities.
PubMedID- 23097000 muscle atrophy in cachexia results from a combination of increased catabolism by cytokine-dependent hyperactivation of various pathways and reduced protein anabolism [138–142].
PubMedID- 21134287 In adult ra patients cachexia with muscle wasting and fat gain is common, and the mechanisms probably include cytokine-driven hypermetabolism during active disease [37,38].
PubMedID- 21475674 This opens a new perspective in understanding muscle wasting associated with cancer cachexia and may lead to new approaches in the design of therapeutic strategies.
PubMedID- 21966644 Cancer cachexia is a condition of progressive muscle wasting that develops as a secondary condition in response to tumour growth [1].
PubMedID- 24685128 Leucine supplementation is also increasingly being recommended to reduce the muscle wasting that occurs with cancer cachexia [20].
PubMedID- 24251822 cachexia presents with ongoing muscle wasting, altering quality of life in cancer patients.
PubMedID- 22473907 We also chose to analyze snps based on 18 genes identified in a gene expression study on muscle wasting in patients with cancer cachexia (stephens et al, 2010).
PubMedID- 21949739 muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation.
PubMedID- 26137861 Rationale: skeletal muscle wasting with accompanying cachexia is a life threatening complication in congestive heart failure.
PubMedID- 24877061 Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes.

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