eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | multiple endocrine neoplasia type 1 |
| Comorbidity | C0302592|cervical carcinoma |
| Sentences | 1 |
| PubMedID- 24659184 | Low-grade sils often regress and only a minority of women infected with hpv develop cervical carcinoma, with malignant progression involving a long latent period where additional ‘hits’ are needed 3. an important feature of cervical carcinogenesis is genomic instability caused by deregulated expression of hr-hpv oncogenes in proliferating epithelial cells 4. these changes lead to the selection of particular genomic copy number imbalances, which are likely to provide a selective advantage through altered expression of ‘driver’ host genes. |
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