eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | multiple endocrine neoplasia type 1 |
| Comorbidity | C0032000|pituitary adenomas |
| Sentences | 3 |
| PubMedID- 25494863 | Tumor tissue analysis identified loh at the sdhb locus in three pituitary adenomas and loss of heterozygosity at the men1 locus in two pheochromocytomas. |
| PubMedID- 21613050 | Many familial cases of pituitary adenomas can be attributed to mutations in men1 and prkar1a genes. |
| PubMedID- 25350067 | In this review, we describe the clinical features of patients with sporadic pituitary adenomas that are associated with aip or men1 mutations, and discuss the molecular mechanisms that might be involved in pituitary adenoma tumorigenesis. |
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