eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | multiple endocrine neoplasia type 1 |
| Comorbidity | C0032000|pituitary adenoma |
| Sentences | 5 |
| PubMedID- 21613050 | Many familial cases of pituitary adenomas can be attributed to mutations in men1 and prkar1a genes. |
| PubMedID- 23334809 | The purpose of this study it was to evaluate the frequency of multiple endocrine neoplasia type 1 (men1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those individuals afflicted with men1. |
| PubMedID- 25350067 | In this review, we describe the clinical features of patients with sporadic pituitary adenomas that are associated with aip or men1 mutations, and discuss the molecular mechanisms that might be involved in pituitary adenoma tumorigenesis. |
| PubMedID- 25494863 | Tumor tissue analysis identified loh at the sdhb locus in three pituitary adenomas and loss of heterozygosity at the men1 locus in two pheochromocytomas. |
| PubMedID- 20367983 | Conclusions: the mutation in exon 10 of men1 gene might induce development of parathyroid hyperplasia and pituitary adenoma and cosegregate with men1 syndrome. |
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