eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | monoclonal gammopathy of uncertain significance |
| Comorbidity | C1136085|monoclonal gammopathy |
| Sentences | 127 |
| PubMedID- 22360869 | Heavy light chain serum immunoassays are used in patients with multiple myeloma and monoclonal gammopathy of undetermined significance (mgus); they can provide quantitative information and be of prognostic significance in these patients [12,13]. |
| PubMedID- 24416592 | Multiple myeloma develops secondary to a benign monoclonal gammopathy of undetermined significance (mgus) [76]. |
| PubMedID- 25421383 | Mm typically evolves from a premalignant condition called monoclonal gammopathy of undetermined significance (mgus), with m (monoclonal)-protein detected in blood or urine. |
| PubMedID- 24868448 | During the same period, five patients underwent bone-marrow aspiration for a reason other than a hematological disorder, that is, suspected posttransplant lymphoproliferative disease (n = 4) and monoclonal gammopathy of undetermined significance (n = 1). |
| PubMedID- 24517398 | For example, some patients with monoclonal gammopathy of uncertain significance (mgus), a condition characterized by the presence of a monoclonal immunoglobulin protein present in the serum, can progress to multiple myeloma [9]. |
| PubMedID- 26015785 | The association between monoclonal gammopathy of undetermined significance (mgus) and pg is 7–9% [3]. |
| PubMedID- 22899948 | In contrast, in monoclonal gammopathy of undetermined significance (mgus), a common disorder of aging and a precursor lesion to mm, tumor cells express high levels of mica whereas low levels of smica are detected in peripheral blood. |
| PubMedID- 22303318 | Multiple myeloma develops from a benign condition called monoclonal gammopathy of undetermined significance (mgus) (weiss et al., 2009). |
| PubMedID- 25706753 | However, their subjects included patients with not only asymptomatic myeloma, but also monoclonal gammopathy of undetermined significance (mgus), which is a common premalignant plasma cell disorder, raising concern about the skewed diagnostic performance of variables in differentiating disease status. |
| PubMedID- 25794164 | monoclonal gammopathy of undetermined significance (mgus) is a premalignant stage that can progress to mm, a malignant plasma cell neoplasia [1,2]. |
| PubMedID- 24391641 | monoclonal gammopathy of undetermined significance (mgus) is a common disorder of aging and a precursor lesion to multiple myeloma (mm). |
| PubMedID- 22742514 | monoclonal gammopathy of undetermined significance (mgus) is one of the most common premalignant disorders in western countries. |
| PubMedID- 24009431 | monoclonal gammopathy of undetermined significance (mgus) is the most common immunoglobulin (ig) disorder, with an estimated prevalence of 5% in persons above 70 years of age.1 patients with mgus are at increased risk of malignant transformation to symptomatic malignant monoclonal gammopathy, most often multiple myeloma and less frequently another malignant lymphoproliferative disorder. |
| PubMedID- 20300549 | monoclonal gammopathy of undetermined significance (mgus) is rarely complicated by amyloidosis. |
| PubMedID- 24895570 | The myd88 l265p mutation can also be found in patients with igm monoclonal gammopathy of unknown significance (igm mgus) at a lower frequency than wm, ranging from 10 to 87% [10, 18, 19]. |
| PubMedID- 24778994 | monoclonal gammopathy of undetermined significance (mgus) is an asymptomatic plasma cell disorder; it is a non malignant common condition affecting at least 3% of the population above the age of 50, with an average 1% annual risk of progression to multiple myeloma (mm) [1]. |
| PubMedID- 20671999 | Patients with monoclonal gammopathy of undetermined significance and multiple myeloma are at increased risk of venous thromboembolic events with a baseline prevalence of approximately 10% [56]. |
| PubMedID- 25589891 | Increased plasma and bone marrow kyna concentrations have been detected in monoclonal gammopathy of undetermined significance and multiple myeloma patients 7. some authors reported overall activation of kynurenine metabolic route in malignant diseases. |
| PubMedID- 22481966 | Individuals with multiple myeloma must be distinguished from those with monoclonal gammopathy of undetermined significance (mgus) (<10% plasma cells in bone marrow, low levels of m-protein (<3 g/dl), and no osteolytic lesion), amyloidosis, or other lymphoproliferative disorders with paraproteinemia [36]. |
| PubMedID- PMC4034030 | In multiple myeloma bone marrow angiogenesis measured as microvascular density increases with progression from monoclonal gammopathy of undetermined significance (mgus) to nonactive multiple myeloma and active multiple myeloma, and is related with the plasma cell labeling index [8]. |
| PubMedID- 20890394 | It was shown that nfkb activation in mm tumors results mainly from extrinsic signaling by april and baff ligands that stimulate receptors on normal plasma cells as well as on pre-malignant monoclonal gammopathy of undetermined significance (mgus) and mm tumors. |
| PubMedID- 22983434 | It is now widely accepted that most, if not all, mm is preceded by a premalignant disease known as monoclonal gammopathy of uncertain significance (mgus).19 mgus is characterised by the abnormal proliferation of plasma cells in the bone marrow, while the patients remain asymptomatic.20 the signals that lead to the initiation of excessive plasma cell proliferation are, therefore, present within the bone marrow microenvironment before the onset of overt mm. |
| PubMedID- 22961061 | Multiple myeloma (mm) is an incurable hematological disorder in which malignant plasma cells accumulate in the bone marrow and is primarily distinguished from other premalignant plasma cell disorders, such as monoclonal gammopathy of unknown significance or smoldering mm, by the presence of end-organ damage as defined by the crab criteria: hypercalcemia, renal impairment, anemia and bone disease.1 although mm is characterized by a range of genetic aberrations leading to heterogeneity in the patient population, the specific mechanisms leading to the development of plasma cell disorders and progression to symptomatic mm have not been fully elucidated. |
| PubMedID- PMC3002697 | In the years preceding mm diagnosis, a small monoclonal ig develops that may be detectable upon serum protein electrophoresis, resulting in a premalignant condition known as monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 21436884 | Samples contained 8 brain autopsy tissues from 6 patients (6 from 5 hiv-positive patients with pml, 2 from a patient with chronic lymphocytic leukemia(cll)), 62 csf samples from 59 patients (30 from 29 hiv-positive patients with pml, 12 from 12 hiv-negative patients with pml, 6 from 6 hiv-positive patients, 10 from 10 patients immunosuppressed by other diseases and 2 from 2 ms patients), 13 whole blood samples from 13 patients (2 from 2 hiv-negative patients with pml, 2 from 2 hiv-positive lymphoma patients, 3 from lymphoma patients, 2 from 2 patients with monoclonal gammopathy of undetermined significance(mgus), 1 from a patient with thrombocytosis, 1 from a hiv-positive patient with anemia, 1 from a patient with leshmaniasis, 1 from a cll patient), 68 pbmc samples from 49 patients (14 from 14 hiv-positive patients with pml, 10 from 10 hiv-negative patients with pml, 7 from 7 hiv-positive patients, 19 from ms patients prior to natalizumab treatment, 18 from ms patients after natalizumab treatment). |
| PubMedID- 21415967 | Individuals with plasma cell reactions to connective tissue disorders, liver disease, metastatic carcinoma or chronic infections were not included, nor patients with monoclonal gammopathy of undetermined significance,3 smoldering multiple myeloma, solitary plasmacytoma or plasma cell leukemia. |
| PubMedID- 22723846 | Al = light chain amyloidosis; mm = multiple myeloma; mgus = monoclonal gammopathy of undetermined significance; m-protein = monoclonal protein; sflc = serum free light chain concentration in milligrams per deciliter. |
| PubMedID- 24355943 | Mm is preceded by a premalignant condition termed monoclonal gammopathy of undetermined significance (mgus) [5]. |
| PubMedID- 24187560 | Demonstrated that tregs were significantly reduced in monoclonal gammopathy of undetermined significance (mgus) and mm. |
| PubMedID- 22399147 | The remaining patient had an igg monoclonal gammopathy of undetermined significance and a progressive and painful polyneuropathy for which she was treated with sct. |
| PubMedID- 21655047 | monoclonal gammopathy of undetermined significance (mgus) is a benign asymptomatic plasma cell neoplasm containing monoclonal protein (m protein). |
| PubMedID- 22522905 | Of relevance to this study, others have used ighv sequence analysis to better understand the relationship between mm and its known premalignant condition monoclonal gammopathy of undetermined significance (mgus) [23, 24] and have shown that while there is evidence for intraclonal heterogeneity in mgus, mm pcs are homogeneous [17, 25-27]. |
| PubMedID- 26484033 | He was ultimately diagnosed with monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 22654917 | The 48 patients with other disorders included 33 with sjögren's syndrome, 3 with multicentric castleman's disease (mcd), 3 with b-cell lymphoma, 2 with sarcoidosis, and 1 each with kimura's disease, ulcerative colitis, autoimmune hepatitis, igg-type monoclonal gammopathy of undetermined significance, progressive transformation of the germinal center, scleritis, and severe keratoconjunctivitis sicca. |
| PubMedID- 24877060 | The most frequent diseases include monoclonal gammopathy of undetermined significance (mgus), both asymptomatic (smoldering) and symptomatic multiple myeloma (mm), solitary plasmacytoma, and immunoglobulin light chain amyloidosis (al amyloidosis) [3]. |
| PubMedID- 25852576 | In hematological malignancy, cd9 expression has been studied in multiple myeloma and monoclonal gammopathy of unknown significance (mgus), which precedes myeloma development. |
| PubMedID- 25125903 | In contrast, patients with mm presented at an advanced stage with multiple lytic bone lesions; three had plasmacytoma (rib/sternum/right kidney), and one had monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 24314019 | Nearly all mm patients derive from asymptomatic monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 20234811 | The patient was otherwise healthy except for ulcerative colitis, which required colectomy 24 years ago, and monoclonal gammopathy of unknown significance (igg λ-light chain, 1.48 g/dl) diagnosed 14 years earlier. |
| PubMedID- 22988469 | monoclonal gammopathy of undetermined significance (mgus) has been recognized as another lymphoproliferative disorder in hcv-related mc [131]. |
| PubMedID- 25405070 | Although a monoclonal gammopathy of unknown significance (mgus) is highly associated with scls [3,4], its pathophysiologic significance is unclear. |
| PubMedID- 26000300 | It represents an intermediate stage between monoclonal gammopathy of undetermined significance (mgus) and symptomatic mm. |
| PubMedID- 25615546 | Multiple myeloma (mm) is a pc malignancy that is nearly always preceded by monoclonal gammopathy of undetermined significance (mgus) [11]. |
| PubMedID- 24716444 | Samples were from healthy individuals (npc; n = 22); patients with monoclonal gammopathy of undetermined significance (mgus; n = 14); smouldering multiple myeloma (smm; n = 34); multiple myeloma (mm; n = 344), and human myeloma cell lines (hmcl; n = 45). |
| PubMedID- 24489445 | To this aim, we analyzed the signals implemented by monoclonal antibodies (mab) ligation in peripheral blood mononuclear cells (pbmc) obtained from mm patients and compared to benign monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 25695044 | Few years ago, it became evident that all myelomas are preceded by monoclonal gammopathy of undetermined significance [11]. |
| PubMedID- 26137529 | However, these chromosomal abnormalities are also observed in monoclonal gammopathy of unknown significance and genetic mutations have also been described as potent drivers of mm pathogenesis. |
| PubMedID- 24534189 | The aforementioned experiments reveal that tolerance to nucleic acid-sensing tlrs is disrupted by a somatic mutation in myd88 that is very frequently found in the benign disorder, igm monoclonal gammopathy of undetermined significance, and in a range of b cell malignancies. |
| PubMedID- 22947336 | (b and d) in 42 monoclonal gammopathy of undetermined significance (mgus) patients, 46 multiple myeloma (mm) patients and nc (healthy donors). |
| PubMedID- 25929340 | Strikingly, the data parallel ighv clonal sequences in some monoclonal gammopathy of undetermined significance (mgus) known to display on-going shm imprints. |