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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease monoclonal gammopathy of uncertain significance
Comorbidity C0026470|monoclonal gammopathy of unknown significance
Sentences 21
PubMedID- 24429703 Mm undergoes a multistep transformation process and its genetic landscape changes over time due to additional events such as somatic mutations, epigenetic and chromosomal copy-number changes driving its progression from monoclonal gammopathy of unknown significance to symptomatic mm and ultimately to aggressive extramedullary disease in some patients4.
PubMedID- 24198984 Our patient was found to have a monoclonal gammopathy of unknown significance (mgus) with 0.43 grams of igg kappa.
PubMedID- 25852576 In hematological malignancy, cd9 expression has been studied in multiple myeloma and monoclonal gammopathy of unknown significance (mgus), which precedes myeloma development.
PubMedID- 24032087 Rare cases may develop in association with a paraproteinemia such as monoclonal gammopathy of unknown significance (mgus).
PubMedID- 26157944 The patient's medical history was significant for hypertension, colonic adenomas, and igm monoclonal gammopathy of unknown significance (mgus).
PubMedID- 24808988 Scls is often accompanied by a monoclonal gammopathy of unknown significance (mgus).
PubMedID- 21734887 Plasma cell dyscrasia may manifest as plasmacytoma, multiple myeloma (mm), primary amyloidosis, or monoclonal gammopathy of unknown significance [1].
PubMedID- 25405070 Although a monoclonal gammopathy of unknown significance (mgus) is highly associated with scls [3,4], its pathophysiologic significance is unclear.
PubMedID- 20234811 The patient was otherwise healthy except for ulcerative colitis, which required colectomy 24 years ago, and monoclonal gammopathy of unknown significance (igg λ-light chain, 1.48 g/dl) diagnosed 14 years earlier.
PubMedID- 25605012 We performed expression analysis to determine whether hspa5 expression was upregulated in patients with the pre-malignant condition monoclonal gammopathy of unknown significance (mgus) that nearly uniformly precedes mm.
PubMedID- 24171046 In patients without symptoms, monoclonal igm elevation and with bone marrow plasma cells less than 10%, igm-monoclonal gammopathy of unknown significance (mgus) should also be kept in the list of differential diagnosis.
PubMedID- 24895570 The myd88 l265p mutation can also be found in patients with igm monoclonal gammopathy of unknown significance (igm mgus) at a lower frequency than wm, ranging from 10 to 87% [10, 18, 19].
PubMedID- 25861350 She was diagnosed with monoclonal gammopathy of unknown significance (mgus) and autoimmune hemolytic anemia 4 years ago, and treated with cyclophosphamide previously.
PubMedID- 25887188 Patients presenting with previously untreated mm (n = 332) or monoclonal gammopathy of unknown significance (mgus; n = 22) at the university hospitals of heidelberg and montpellier (hm group) as well as 10 healthy normal donors have been included in the study approved by the heidelberg ethics committee (#229/2003 and s-152/2010) after written informed consent was obtained in accordance with the declaration of helsinki.
PubMedID- 22919534 The lupus anticoagulant is a polyclonal immunoglobulin type igg; it has been reported in autoimmune disease, monoclonal gammopathy of unknown significance, and aids.
PubMedID- 24317090 Patients 1 and 2 suffered from concomitant neutropenia, whereas patient 2 also had anemia and monoclonal gammopathy of unknown significance that had not required treatment thus far.
PubMedID- 22335280 While a monoclonal gammopathy of unknown significance (mgus) may develop to systemic amyloidosis or myeloma (23) this does not seem to happen with a localized plasma cell clone associated with localized amyloidosis, which almost never progresses to a systemic disease (20,24,25).
PubMedID- 22961061 Multiple myeloma (mm) is an incurable hematological disorder in which malignant plasma cells accumulate in the bone marrow and is primarily distinguished from other premalignant plasma cell disorders, such as monoclonal gammopathy of unknown significance or smoldering mm, by the presence of end-organ damage as defined by the crab criteria: hypercalcemia, renal impairment, anemia and bone disease.1 although mm is characterized by a range of genetic aberrations leading to heterogeneity in the patient population, the specific mechanisms leading to the development of plasma cell disorders and progression to symptomatic mm have not been fully elucidated.
PubMedID- 26137529 However, these chromosomal abnormalities are also observed in monoclonal gammopathy of unknown significance and genetic mutations have also been described as potent drivers of mm pathogenesis.
PubMedID- 25886604 Because cidp has an autoimmune basis, it can occur in association with diseases such as hiv infection and hepatitis c, sjogren's syndrome, monoclonal gammopathy of unknown significance, melanoma, lymphoma, diabetes and inflammatory bowel diseases [12].
PubMedID- 23232072 We investigated ido1 expression in 25 consecutive patients with symptomatic mm and in 7 patients with either monoclonal gammopathy of unknown significance (mgus; n=3) or smoldering mm (smm; n=4).

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