eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | monoclonal gammopathy of uncertain significance |
| Comorbidity | C0026470|monoclonal gammopathy of undetermined significance |
| Sentences | 92 |
| PubMedID- 24574631 | [23] even though, it is considered as a single disease, there are many clinical entities (monoclonal gammopathy of undetermined significance, smoldering mm, waldenstrom's macrog lobulinemia, solitary plasmacytoma, systemic amyloidosis, poems syndrome) and cytogenetically distinct entities (translocation of genes (11;14), t (4;14), t (14;16), t (6;14), t (14;20), hyperdiploidy and deletion of 17p), that are currently lumped together; hence, there is an element of subjectivity involved in interpreting the clinical criteria for diagnosis and hence, deciding on therapeutic requirements. |
| PubMedID- 20300549 | Past medical history was significant for hypertension, hypercholesterolemia, aortic valve replacement (nonmetallic), atrial fibrillation (on warfarin), incomplete heart block, pacemaker, and igg- iga, kappa type monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 22742514 | A study that examined whether monoclonal gammopathy of undetermined significance (mgus) is increased in first-degree relatives of multiple myeloma (mm) or mgus patients report that there was an increased risk of mgus in first-degree relatives (age-adjusted risk ratio [rr], 2.6; 95% ci, 1.9 to 3.4) compared with the reference population[18]. |
| PubMedID- 26000300 | It represents an intermediate stage between monoclonal gammopathy of undetermined significance (mgus) and symptomatic mm. |
| PubMedID- 20809955 | In particular, among the most common laboratory tests used are those for vitamin b12 levels (to rule out subacute combined degeneration), parathyroid hormone levels (to rule out hyperparathyroidism), and serum protein electrophoresis with immunofixation (to rule out multiple myeloma or monoclonal gammopathy of undetermined significance (mgus)). |
| PubMedID- 22899948 | In contrast, in monoclonal gammopathy of undetermined significance (mgus), a common disorder of aging and a precursor lesion to mm, tumor cells express high levels of mica whereas low levels of smica are detected in peripheral blood. |
| PubMedID- 24877060 | The most frequent diseases include monoclonal gammopathy of undetermined significance (mgus), both asymptomatic (smoldering) and symptomatic multiple myeloma (mm), solitary plasmacytoma, and immunoglobulin light chain amyloidosis (al amyloidosis) [3]. |
| PubMedID- 24326130 | The 162 samples evaluated represented 15 healthy individuals (normal), 22 patients with monoclonal gammopathy of undetermined significance (mgus), 24 with smoldering mm (smm), 74 with newly diagnosed mm (mm-n), and 27 with relapsed/refractory mm (mm-r). |
| PubMedID- 25929340 | Strikingly, the data parallel ighv clonal sequences in some monoclonal gammopathy of undetermined significance (mgus) known to display on-going shm imprints. |
| PubMedID- 24563807 | Cks1 gain is associated with transformation from benign monoclonal gammopathy of undetermined significance (mgus) to more aggressive forms mm and plasma cell leukemias (pcl) and a shorter disease free survival [127]. |
| PubMedID- 21411633 | Tβriii mrna expression was decreased during multiple myeloma progression, with decreased expression in bone marrow specimens from patients with monoclonal gammopathy of undetermined significance (mgus) relative to normal patients, and was decreased in bone marrow from multiple myeloma patients relative to bone marrow from mgus patients (mattioli et al., 2005; zhan et al., 2006) (supplemental figure s1, summarized in supplemental table s1). |
| PubMedID- 20825629 | The most important risk factor is igm monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 25838973 | The mean fancd2 mrna level in myeloma cells (351 ± 268, n = 351) was 4.3-fold higher than in normal plasma cells (npcs) from the bone marrow (81.2 ± 54.1, n = 22) and 1.8-fold higher than in plasma cells from individuals with monoclonal gammopathy of undetermined significance (mgus; 195 ± 207, n = 44). |
| PubMedID- 26484033 | monoclonal gammopathy of undetermined significance (mgus) can also be associated with peripheral neuropathy [5]. |
| PubMedID- 22723846 | In patients with light chain amyloidosis, multiple myeloma and monoclonal gammopathy of undetermined significance, immunoreactive proteins corresponding to monomeric light chains were found in exosomes by western blot. |
| PubMedID- 24359546 | A 64 year-old woman with al-amyloidosis secondary to a monoclonal gammopathy of undetermined significance (mgus) referred to our hospital for acute painless drop of vision due to bilateral aion. |
| PubMedID- 21655047 | She was diagnosed with monoclonal gammopathy of undetermined significance. |
| PubMedID- 24895568 | monoclonal gammopathy of undetermined significance (mgus) is the most common plasma cell disorder, and its prevalence increases with age [1–4]. |
| PubMedID- 24466560 | In fact, an igm monoclonal component can be found in other lymphoproliferative disorders, such as chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll), splenic marginal zone lymphoma (smzl), diffuse large cell lymphoma (dlcl), mantle cell lymphoma (mcl), myeloma and igm monoclonal gammopathy of undetermined significance (igm-mgus)(table 1). |
| PubMedID- 25125903 | In contrast, patients with mm presented at an advanced stage with multiple lytic bone lesions; three had plasmacytoma (rib/sternum/right kidney), and one had monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 21785257 | monoclonal gammopathy of undetermined significance is the most common plasma cell dyscrasia, accounting for more than 60% of these diseases. |
| PubMedID- 24504138 | Generally, mm is preceded by two premalignant conditions namely monoclonal gammopathy of undetermined significance (mgus) and smoldering (asymptomatic) multiple myeloma (smm) [3, 4]. |
| PubMedID- 24778994 | monoclonal gammopathy of undetermined significance (mgus) is an asymptomatic plasma cell disorder; it is a non malignant common condition affecting at least 3% of the population above the age of 50, with an average 1% annual risk of progression to multiple myeloma (mm) [1]. |
| PubMedID- 25421383 | Mm typically evolves from a premalignant condition called monoclonal gammopathy of undetermined significance (mgus), with m (monoclonal)-protein detected in blood or urine. |
| PubMedID- PMC4034030 | In multiple myeloma bone marrow angiogenesis measured as microvascular density increases with progression from monoclonal gammopathy of undetermined significance (mgus) to nonactive multiple myeloma and active multiple myeloma, and is related with the plasma cell labeling index [8]. |
| PubMedID- 22826793 | She was diagnosed as having non-secretory ige myeloma with igg monoclonal gammopathy of undetermined significance. |
| PubMedID- 20890394 | It was shown that nfkb activation in mm tumors results mainly from extrinsic signaling by april and baff ligands that stimulate receptors on normal plasma cells as well as on pre-malignant monoclonal gammopathy of undetermined significance (mgus) and mm tumors. |
| PubMedID- 24813078 | Mm is also an excellent cancer model to study because it is preceded by an asymptomatic premalignant stage called monoclonal gammopathy of undetermined significance and the development of mm involves sequential acquisition of various gene mutations (figure 1a). |
| PubMedID- 26015785 | The association between monoclonal gammopathy of undetermined significance (mgus) and pg is 7–9% [3]. |
| PubMedID- 24716444 | Samples were from healthy individuals (npc; n = 22); patients with monoclonal gammopathy of undetermined significance (mgus; n = 14); smouldering multiple myeloma (smm; n = 34); multiple myeloma (mm; n = 344), and human myeloma cell lines (hmcl; n = 45). |
| PubMedID- 21533133 | monoclonal gammopathy of undetermined significance (mgus) is a paraproteinemic disorder and a possible cause for slowly progressive symmetric distal sensorimotor neuropathy. |
| PubMedID- 25789189 | A 70-year-old caucasian male with monoclonal gammopathy of undetermined significance (mgus) and high risk adenocarcinoma of the prostate (t3b, gleason score: 3 + 4 = 7, prebiopsy psa: 74.3 ng/ml) who completed external beam radiation therapy to the prostate, periprostatic lymphatics, seminal vesicles, and regional pelvic lymphatics concurrent with adt (leuprolide 22.5 mg im every 3 months) was found to have evidence of sclerotic and blastic bony lesions, suspicious for metastatic prostatic cancer, 6 months following primary therapy with restaging imaging (figure 3). |
| PubMedID- 20532146 | monoclonal gammopathy of undetermined significance (mgus) is a diagnosis given to patients with monoclonal gammopathy who have no features of multiple myeloma or other malignant disorders. |
| PubMedID- 22988469 | monoclonal gammopathy of undetermined significance (mgus) has been recognized as another lymphoproliferative disorder in hcv-related mc [131]. |
| PubMedID- 22947336 | (b and d) in 42 monoclonal gammopathy of undetermined significance (mgus) patients, 46 multiple myeloma (mm) patients and nc (healthy donors). |
| PubMedID- 24416592 | Multiple myeloma develops secondary to a benign monoclonal gammopathy of undetermined significance (mgus) [76]. |
| PubMedID- 24187560 | Demonstrated that tregs were significantly reduced in monoclonal gammopathy of undetermined significance (mgus) and mm. |
| PubMedID- 26077418 | Methods: serum samples from mm, monoclonal gammopathy of undetermined significance (mgus) and healthy patients were collected and stored at −80°c. |
| PubMedID- 24009431 | monoclonal gammopathy of undetermined significance (mgus) is the most common immunoglobulin (ig) disorder, with an estimated prevalence of 5% in persons above 70 years of age.1 patients with mgus are at increased risk of malignant transformation to symptomatic malignant monoclonal gammopathy, most often multiple myeloma and less frequently another malignant lymphoproliferative disorder. |
| PubMedID- 25589891 | Increased plasma and bone marrow kyna concentrations have been detected in monoclonal gammopathy of undetermined significance and multiple myeloma patients 7. some authors reported overall activation of kynurenine metabolic route in malignant diseases. |
| PubMedID- 22567028 | Mm can occur de novo or evolve from benign monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 24428816 | Mgus: monoclonal gammopathy of undetermined significance. |
| PubMedID- 20086168 | Similarly, cr was not a surrogate marker for survival in patients whose disease had evolved from monoclonal gammopathy of undetermined significance (mgus) or smoldering mm [9], although newer data indicate that all or almost all myelomas arise from a mgus precursor state. |
| PubMedID- 24224040 | Monoclonal igm protein (igm m-protein) is observed in wm, diffuse large b-cell lymphoma (dlbcl), chronic lymphocytic leukemia, monoclonal gammopathy of undetermined significance (mgus), and autoimmune disease. |
| PubMedID- 22360869 | Heavy light chain serum immunoassays are used in patients with multiple myeloma and monoclonal gammopathy of undetermined significance (mgus); they can provide quantitative information and be of prognostic significance in these patients [12,13]. |
| PubMedID- 24868448 | During the same period, five patients underwent bone-marrow aspiration for a reason other than a hematological disorder, that is, suspected posttransplant lymphoproliferative disease (n = 4) and monoclonal gammopathy of undetermined significance (n = 1). |
| PubMedID- 20528908 | Bone formation is primarily impaired in patients with overt osteolysis, whereas no decrease in bone formation is observed in mm without osteolysis or in monoclonal gammopathy of undetermined significance (mgus) (7, 12). |
| PubMedID- 24391642 | monoclonal gammopathy of undetermined significance (mgus) consistently preceded development of mm. |
| PubMedID- 22654917 | The 48 patients with other disorders included 33 with sjögren's syndrome, 3 with multicentric castleman's disease (mcd), 3 with b-cell lymphoma, 2 with sarcoidosis, and 1 each with kimura's disease, ulcerative colitis, autoimmune hepatitis, igg-type monoclonal gammopathy of undetermined significance, progressive transformation of the germinal center, scleritis, and severe keratoconjunctivitis sicca. |
| PubMedID- 25768011 | These findings may provide some rational for treating patients with monoclonal gammopathy of undetermined significance or smouldering mm i.e. |
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