eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | metabolic syndrome x |
| Comorbidity | C0028754|obesity |
| Sentences | 300 |
| PubMedID- 26537270 | Background -overweight and obesity are associated with metabolic syndrome and abdominal obesity, thereby increasing the risk of type 2 diabetes mellitus and cardiovascular diseases. |
| PubMedID- 22041693 | obesity is associated with metabolic syndrome, a cluster of symptoms including diabetes, hyperlipidemia, hypertension and arteriosclerosis, which can cause serious health problems. |
| PubMedID- 24767168 | However, we could reach the statistical significance in the multiple linear regression models including visceral obesity (i.e., key component of the metabolic syndrome). |
| PubMedID- 20852030 | We hypothesized that overweight and obesity, regardless of metabolic syndrome status, as well as the metabolic syndrome, regardless of bmi status, would be associated with long-term increased risk for diabetes. |
| PubMedID- 21842287 | It is a well-known fact that severe obesity is associated with the metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension, and other diseases. |
| PubMedID- 23354399 | Cardiometabolic syndrome occurs with obesity and consists of pathophysiological factors that increase the risk for cardiovascular events. |
| PubMedID- 21834955 | The relationship between depression and waist circumference or abdominal obesity as a component of metabolic syndrome has been explored previously in studies examining the associations of metabolic syndrome with mental illness [39-43]. |
| PubMedID- 21147642 | The prevalence of the pediatric metabolic syndrome in children with obesity is growing much more rapidly in developing countries than in industrialized countries [37]. |
| PubMedID- 23201770 | These results suggest that tocotrienols protect the heart and liver, and improve plasma glucose and lipid profiles with minimal changes in abdominal obesity in this model of human metabolic syndrome. |
| PubMedID- 24740690 | Particularly, due to the pathophysiological relevance of acc2 in lipid metabolic syndrome associated with obesity, diabetes, cancer, and cardiovascular disease, acc2 activity regulation has been considered as a candidate target for therapeutic interventions, which essentially requires authentic bioengineered recombinant proteins (abu-elheiga et al. |
| PubMedID- 20835560 | Da-paz-filho et al.13 described a decrease in leptin production by adipose tissue in obesity associated with severe metabolic syndrome, suggesting a state of relative leptin deficiency in obesity that is associated with advanced stages of the syndrome. |
| PubMedID- 22846254 | Patients with sustained obesity and features of the metabolic syndrome had a worse 1-year mortality rate of 42%. |
| PubMedID- 25621503 | It is well known that an increase in adipokine production can influence glucose metabolism, insulin sensitivity and inflammation, and this finding could represent a molecular link between obesity and the development of diabetes mellitus, metabolic syndromes and cardiovascular diseases [77]. |
| PubMedID- 22315154 | Aim: the aim of this study was to determine the prevalence of erectile dysfunction (ed), testosterone deficiency syndrome (tds), and metabolic syndrome in patients with abdominal obesity (ao) and the prevalence of morbidity at different levels of testosterone (tst). |
| PubMedID- 21562062 | Relationships among insulin resistance, obesity, diagnosis of the metabolic syndrome and cardio-metabolic risk. |
| PubMedID- 24701367 | The metabolic syndrome commonly associated with obesity may lead to insulin resistance, rendering the body less adept at maximally utilizing glucose, a breakdown product of carbohydrates [175]. |
| PubMedID- 25648310 | The aim of this study was to evaluate the relationship between platelet indices, including mean platelet volume, and abdominal obesity in patients with metabolic syndrome. |
| PubMedID- 25514913 | Specific co-morbidities correlated to the presence of obesity and associated with metabolic syndrome should always be ruled out in patients affected by nash-related end-stage liver disease, who are potential candidates for liver transplantation. |
| PubMedID- 23197236 | [38] demonstrated that obesity, as a component of metabolic syndrome, was independently associated with advanced fibrosis. |
| PubMedID- 24847618 | Background: obesity-induced metabolic syndrome is a multiple risk factor for cardiovascular (cv) risk factors and type 2 diabetes, and ethnic minorities seem to have unfavourable medical risk factors in general more frequently than majority populations. |
| PubMedID- 21378565 | Purpose of review: the metabolic syndrome incorporating obesity, hypertension, dyslipidaemia and elevated plasma glucose has reached epidemic proportions in many western countries leading to a dramatic increase in insulin resistance, steatosis and type 2 diabetes. |
| PubMedID- 25134788 | Objective: non-alcoholic fatty liver disease (nafld) is closely linked to obesity and constitutes part of the metabolic syndrome, which have been associated with low serum vitamin d (vd). |
| PubMedID- 24269186 | In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (mets) in a children population from china. |
| PubMedID- 22041985 | Childhood obesity and risk of the adult metabolic syndrome: a systematic review. |
| PubMedID- 21187874 | Evaluated the association of metabolic syndrome with obesity measures, metabolic profiles, and intake of dietary fatty acids. |
| PubMedID- 25115695 | Hypertension, diabetes mellitus (especially type 2 diabetes mellitus) and metabolic syndrome associated with obesity are rapidly growing public health problems. |
| PubMedID- 22277936 | Insulin resistance and obesity are components of the metabolic syndrome that includes development of cardiovascular disease and diabetes with advancing age. |
| PubMedID- 25679397 | Effects of metabolic syndrome with or without obesity on outcomes after coronary artery bypass graft. |
| PubMedID- 20562852 | For instance, our previous studies in clockδ19/δ19 mutant mice showed that these mice are susceptible to obesity and certain features of metabolic syndrome including steatosis, adipose hypertrophy, and hyperlipidemia, due to primary defects within both hypothalamus (decreased anorexigenic peptidergic signaling), and also within liver. |
| PubMedID- 25861250 | The oa-no2, a nitrated fatty acid and an endogenous ppars agonist, has been reported to have relevant biological effects on inflammation [11], hypertension [12], vascular neointimal proliferation [13], obesity with metabolic syndrome [7], hyperglycemia [14], and proteinuria [15] in diabetes without side effects. |
| PubMedID- 22546774 | Background: fatty liver disease (fld) is characterized by increased intrahepatic triglyceride content with or without inflammation and is associated with obesity, and features of the metabolic syndrome. |
| PubMedID- 23556000 | Normal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income country. |
| PubMedID- PMC4150581 | (central) obesity is a hallmark of the metabolic syndrome of which the other components are: dyslipidaemia, hypertension, impaired glucose metabolism, with insulin resistance and diabetes type 2. particularly if poorly controlled, there is a significant association between low level of total testosterone or dhea-s and indices of poorly controlled type 2 diabetes. |
| PubMedID- 25586249 | obesity is associated with the metabolic syndrome. |
| PubMedID- 24265520 | Another current hypothesis proposes that obesity is associated with metabolic syndrome, which activates molecular processes that are mitogenic in breast epithelial cells and stimulates neoplasia. |
| PubMedID- 23016134 | One mechanism that may explain microbial-induced obesity associated with metabolic syndrome and t2d, is endotoxemia which is characterized by excess circulating lps which triggers systemic inflammation [81,82]. |
| PubMedID- 19908023 | The predictors hyperglycaemia and central obesity are part of the insulin resistance syndrome [24]. |
| PubMedID- 24864249 | obesity, as part of the metabolic syndrome, is one of the major risk factors in the development of fatty liver [1, 2]. |
| PubMedID- 21310886 | 1) or excluding abdominal obesity from the definition of the metabolic syndrome (supplementary fig. |
| PubMedID- 24082792 | Hypertension has been described as one of the most important factors for the development of metabolic syndrome,27,29–31 together with central obesity.27,30,31 however, the criteria for central obesity also differed among the various studies, some of which measured it according to waist circumference while others used the body mass index. |
| PubMedID- 23696677 | Some studies have suggested that the metabolic syndrome (including obesity) may be associated with dkd in type 1 diabetes. |
| PubMedID- 25430602 | Pcos is underpinned by insulin resistance and is associated with comorbidities including hypertension, dyslipidemia, obesity, and increased risk of metabolic syndrome and type 2 diabetes mellitus [12–15]. |
| PubMedID- 22474523 | Type 2 dm can induce insulin resistance syndrome, which is associated with obesity, hyperlipidemia, hypertension, atherosclerotic heart disease, and other systemic diseases [3, 4]. |
| PubMedID- 21176200 | Results from the multiple regression analysis showed that insulin resistance and obesity were associated with the metabolic syndrome. |
| PubMedID- 23206662 | In humans, evidence suggests that the obesity-related morbidities associated with metabolic syndrome, including diabetes and cardiovascular disease, are caused by an increase in the production of advanced glycoxidation end-products (ages). |
| PubMedID- 21593202 | obesity is the hallmark of the metabolic syndrome and represents a major global health problem that frequently associates with the development of chronic diseases, including type 2 diabetes and cardiovascular disease (1). |
| PubMedID- 22144985 | This in utero programming seems to create a kind of “metabolic memory,” since physiological anomalies of gestational period are responsible for the onset of diseases in offspring at adulthood, such as type 2 diabetes and obesity associated with metabolic syndrome. |
| PubMedID- 20602679 | Background/aims: abdominal obesity is associated with metabolic syndrome and non-alcoholic fatty liver disease (nafld). |
| PubMedID- 22043167 | However, sim1 heterozygotes were viable but developed early-onset hyperphagic obesity with clinical features of metabolic syndrome. |
| PubMedID- 24071981 | In recent years the literature has shown an increasing interest in paediatric obesity and the onset of diabetes and the metabolic syndrome in adulthood. |