eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | melanoma, malignant |
| Comorbidity | C0686377|cns metastasis |
| Sentences | 3 |
| PubMedID- 22488042 | Conclusions: stage iv melanoma patients without cns metastasis treated with p-stat3 inhibitors in efficacy studies should be stratified based on tumor expression of p-stat3; however since p-stat3 expression is not associated with the risk of cns disease, increased mri surveillance of the brain is not likely necessary. |
| PubMedID- 20098694 | Furthermore, the epothilone sagupilone has demonstrated superior efficacy compared to paclitaxel and temozolomide in a mouse cns metastasis model with mda-mb-435 melanoma [11]; another epothilone, patupilone resulted in tumor regression in a mouse b16 melanoma model [12]. |
| PubMedID- 24455650 | Certain metastatic suppressor genes like nm23 and cd44 play an important role in cns metastasis of malignancies like melanoma, breast cancer, etc. |
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