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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease melanoma, malignant
Comorbidity C0220650|brain metastasis
Sentences 11
PubMedID- 24795353 Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates.
PubMedID- 23824275 Ipilimumab in melanoma patients with brain metastasis: a retro-spective multicentre evaluation of thirty-eight patients.
PubMedID- 25695690 The efficacy of this agent in kit-altered melanoma with brain metastasis is limited.
PubMedID- 24265631 Notably, the finding that tcr gene-engineered t cells were able to traffic to the central nervous system and cause complete responses of brain metastasis in patients with melanoma was not only encouraging but also underscored the strength of t cell therapy toward metastasized and poorly accessible tumors (7).
PubMedID- 23082737 The high rate of brain metastasis in patients with advanced melanoma has been a clinical challenge for oncologists.
PubMedID- 22488042 The current analysis was conducted with samples from patients treated at a single institution, which pursues aggressive surgical and multimodality treatment of metastatic melanoma, including in patients with brain metastasis that could bias these results in a favorable manner.
PubMedID- 20216240 This case and earlier reports provide support for the further evaluation of ipilimumab in melanoma patients with brain metastasis.
PubMedID- 26217117 Moreover, in a pilot study [28] of 24 symptomatic, very advanced melanoma patients with brain metastasis and harbouring a braf v600 mutation were treated safely and effectively with vemurafenib, improving patients’ performance status and quality of life.
PubMedID- 23392133 Angiotropism in primary cutaneous melanoma with brain metastasis: a study of 20 cases.
PubMedID- 22577532 brain metastasis is common in patients with melanoma and represents a significant cause of morbidity and mortality.
PubMedID- 21074062 Surgical and radiation therapy improve the outcome of selected melanoma patients with brain metastasis, while systemic treatment using cytotoxic agents still plays a limited role.

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