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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease melanoma, malignant
Comorbidity C0205748|dysplastic nevi
Sentences 14
PubMedID- 23739694 Members of hereditary melanoma kindreds withdysplastic nevi) screening and interventions have resulted in earlier diagnosis andreduced mortality.40-42 however, familial melanoma only represents 10% of all melanomas.40-42 therefore, there is still much to be done regarding sporadic cm prevention.routine screening for cm has considerable implications in terms of health care costs andunwanted effects on people.
PubMedID- 22734760 Median ac values were higher for melanomas compared with dysplastic and non-dysplastic nevi.
PubMedID- 21647268 In addition, sox4 expression was reduced in metastatic malignant melanoma compared with dysplastic nevi and primary melanoma.
PubMedID- 20496072 We found significantly higher cyclin d3 expression in melanomas as compared with dysplastic nevi.
PubMedID- 24499631 Showed that nqo1 expression is significantly increased in primary melanomas compared with dysplastic nevi and this may occur in the initiation stage of melanoma development[23].
PubMedID- 23381582 Our data showed that fbw7 expression is significantly reduced in primary melanoma compared with dysplastic nevi (p=0.020) and further reduced in metastatic melanoma compared with primary melanoma (p=0.011).
PubMedID- 22970236 Also revealed that nuclear p27kip1 expression was reduced in primary melanomas compared with dysplastic nevi and further reduced in metastatic melanoma, whereas the cytoplasmic p27kip1 was increased in primary and metastatic melanomas compared with dysplastic nevi [18].
PubMedID- 24130172 In fact, kai1 expression is drastically reduced in primary melanoma compared with dysplastic nevi (p = 1.8x10(-4)) and further reduced in metastatic melanoma compared with primary melanoma (p = 9.4 x 10(-15)).
PubMedID- 24927342 Wang et al11 showed decreased ing3 expression in malignant melanoma in comparison with dysplastic nevi and gunduz et al1228 found allelic loss and reduced expression of the ing3 in human head and neck cancers, in line with our findings.
PubMedID- 20204281 Our data showed that nqo1 expression is significantly increased in primary melanomas compared with dysplastic nevi (p=0.015, chi2 test).
PubMedID- 21913010 The association of subsequent melanomas with dysplastic nevi is consistent with the latter being risk factors or risk markers for melanoma.
PubMedID- 25954957 The results showed that nrp1 expression was significantly reduced in common nevi and dysplastic nevi, compared with primary melanoma and metastatic melanoma.
PubMedID- 25562667 We used tissue microarray to study the role of human eukaryotic translation initiation factor 4e (eif4e) in melanoma progression in 448 melanocytic lesions and found that high eif4e expression was significantly increased in primary melanomas compared with dysplastic nevi (p<0.001), and further increased in metastatic melanomas (p<0.001).
PubMedID- 20952589 Sox4 expression was remarkably reduced in metastatic melanoma compared with dysplastic nevi (p < 0.05) and primary melanoma (p < 0.01).

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