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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease melanoma, malignant
Comorbidity C0027962|melanocytic nevi
Sentences 15
PubMedID- 24433184 Semiquantitative evaluation of this expression revealed downregulated expression of rpe65 in malignant melanoma compared with benign melanocytic nevi (p < 0.001).
PubMedID- 23739702 The risk of cutaneous melanoma in melanocytic nevi.
PubMedID- 20086181 We aimed to estimate the population attributable fraction (paf) for melanoma associated with melanocytic nevi using relative risk estimates derived from a systematic review and meta-analysis.
PubMedID- 23785613 When clark in 1969 described the types of melanoma currently recognized, he noted that origin of melanoma from a nevus was “the exception rather than the rule.” [4] fifteen years later, in order to satisfy the concept of multistep carcinogenesis, he returned to the position that melanomas resulted from transformation of melanocytic nevi in what he called “six evident lesional steps of tumor progression,” namely, “1) the common acquired melanocytic nevus; 2) a melanocytic nevus with lentiginous melanocytic hyperplasia, i.e., aberrant differentiation; 3) a melanocytic nevus with aberrant differentiation and nuclear atypia, i.e., melanocytic dysplasia; 4) the radial growth phase of primary melanoma; 5) the vertical growth phase of primary melanoma; and 6) metastatic melanoma.” in regard to melanoma, he contended that “the radial growth phase is .
PubMedID- 21155082 Results and conclusions: with regard to the reported cases, melanomas associated with melanocytic nevi were mainly superficial spreading melanomas and nodular melanomas on the trunk or extremities; alms were rarely associated with nevi, indicating a trend similar to that observed in caucasians.
PubMedID- 22550586 The magnitude of the shift reflects the local stiffness of the tissue, which has shown promising results when comparing benign melanocytic nevi with melanoma [37].
PubMedID- 26528046 In the first part of the study we compared the changes which occurred in melanomas with those in melanocytic nevi (dysplastic and common nevi).
PubMedID- 19830692 Mir-15b and mir-210 were significantly upregulated, mir-34a was significantly downregulated in melanomas compared with melanocytic nevi.
PubMedID- 21876460 Altered expression of stat3 mrna, pstat3, and socs3 protein was observed in melanoma specimens, compared with benign melanocytic nevi.
PubMedID- 24842760 We also characterize the frequency of braf mutations in female genital tract melanomas compared with melanocytic nevi.
PubMedID- 21737053 They also indicate a higher frequency of superficial spreading melanomas and melanomas associated with melanocytic nevi in patients carrying certain mutations in mc1r.
PubMedID- 25692084 In one study, bolognia et al concluded that “a small percentage of ‘small dark dots’ within melanocytic nevi are due to melanoma”, finding 3 (5%) of 59 such nevi to be melanoma [3].
PubMedID- 22906024 Nevertheless, further studies are needed to validate the functional role of 14-3-3 proteins in melanotumorigenesis through the proteomic comparison of different malignant melanoma patients with giant congenital melanocytic nevi.
PubMedID- 22464597 They also indicate a higher frequency of superficial spreading melanomas and melanomas associated with melanocytic nevi in patients carrying certain mutations in mc1r.
PubMedID- 24672253 There have been reports of histological atypia (pseudomelanoma) in patients with melanocytic nevi that were treated by co2 lasers as well as lasers for hair removal.33 racial differences probably also need to be taken into consideration, as in asians, the incidence of melanoma has been reported to be between 0.2 and 2.2 per 100,000, much lower than among whites.34 furthermore, the most common sites for the development of melanoma among people with skin of color are areas not directly exposed to the sun, such as palmar, plantar, subungual, and mucosal surfaces.34 this may account for the liberal use of lasers for the treatment of melanocytic nevi in asian countries on the facial skin.

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