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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease melanoma, malignant
Comorbidity C0025202|melanoma
Sentences 31
PubMedID- 25909885 Moreover, gmps levels are increased in metastatic human melanoma specimens compared with primary melanomas arguing that gmps is an attractive candidate for anti-melanoma therapy.
PubMedID- 23647170 Genital and anorectal mucosal melanoma is associated with cutaneous melanoma in patients and in families.
PubMedID- 23861977 By laser microdissection we were able to selectively dissect and genotype cells either from the nevus or from the melanoma part of 46 melanomas that developed in association with a nevus.
PubMedID- 21722368 Ncm is currently diagnosed according to the following criteria put forth by kadonaga and frieden [10] in 1991: (1) large and/or multiple cmn in association with meningeal melanosis or melanoma, (2) no evidence of cutaneous melanoma, except in patients with histologically benign meningeal lesions, or (3) no evidence of meningeal melanoma, except in patients with histologically benign cutaneous lesions.
PubMedID- 23066913 Methods: from 1990 to 2008, the swedish melanoma register included 97% of all melanomas diagnosed in sweden.
PubMedID- 22912864 Despite the fact that the brafv600 mutation was the single most prevalent mutation in our melanoma population (51% of the melanomas had a brafv600 mutation), 41% of the melanoma tumors contained a pi3k mutation including 10 samples that were wild-type for brafv600 and nras.
PubMedID- 25916655 Background: nodular melanoma (nm), representing 10-30% of all melanomas, plays a major role in global mortality related to melanoma.
PubMedID- 21064111 In conclusion, the patient's age is a strong and independent predictor of melanoma-specific survival in patients with localized melanomas, in patients with positive slns and after the onset of distant metastases.
PubMedID- 22778760 In a mouse melanoma model, complete regression of advanced primary melanomas in the skin and metastases in the lung was achieved by a protocol which consisted of timed treatments of ctx preconditioning, adoptive transfer of tumor-specific cd8+ t cells, viral vector-based vaccinations, and administration of cpg-containing adjuvants [141].
PubMedID- 25610191 Anorectal melanoma represents approximately 0.2-1% of all malignant melanomas and has a poor prognosis, with a median survival of 8 to 23 months after the time of diagnosis.
PubMedID- 23981010 We have compared epidemiological and genetic evidences of the potential role of uv radiation in uveal melanoma with data on cutaneous melanoma.
PubMedID- 24573402 Differentially expressed mirnas were identified in the metastatic melanoma compared with the primary cutaneous melanoma samples and the target genes of hsa-mir-27 were found to be significantly enriched at the transcriptional level.
PubMedID- 23228015 Methods: a single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thickness > 1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009.
PubMedID- 22084644 Conclusions: elderly (>/=70 yrs) melanoma patients present with thicker melanomas and a higher mitotic rate but have fewer sln metastases.
PubMedID- 22848838 Diagnostic source was also significantly related to a family history of melanoma, with significantly more melanomas identified by patients when there was a family history of melanoma (di = 7%, pi = 23%) compared to no family history (di = 67%, pi = 55%), or a family history of other skin cancers (di = 26%, pi = 22%),  (χ2 = 9.7,  p < 0.01).
PubMedID- 21122152 In clinic, bnct has been used in various countries to treat patients with high-grade glioma, melanoma, liver metastasis of colon adenocarcioma, malignant melanomas, oral cancer, and therapeutically refractory, recurrent tumors of the head and neck [3,6,11-15]; while the mechanism of bnct-induced cell death remains unclear.
PubMedID- 26078741 Pulmonary involvement is frequently seen in metastatic melanoma with only 2% of malignant melanoma patients with thorax metastasis presenting with pleural effusions.
PubMedID- 25433395 Mitf e318k has been described as a medium-penetrance gene in melanoma associated with multiple primary melanomas developed in its carriers [50, 51], and as predisposing to renal carcinoma as well [48].
PubMedID- 21417906 Conjunctival melanoma represents only 5% of all melanomas arising in the ocular region and is associated with a high mortality rate.
PubMedID- 22993143 Methods: in this work, we evaluated the plasma and tumor dispositions of an antimelanoma agent, carboplatin, in patients with cutaneous melanoma compared with four different murine melanoma models (one gemm, one human cell line xenograft, and two osts).
PubMedID- 23793214 Desmoplastic melanoma represents a minority of cases of primary cutaneous melanoma (less than 4%).
PubMedID- 20695871 Conjunctival melanoma represents only 1.6% of all non-cutaneous melanoma.
PubMedID- 21423681 Adam10 expression was significantly elevated in melanoma metastases compared with primary melanomas [14].
PubMedID- 24885594 One-hundred twelve patients with histologically-proven diagnosis of multiple melanoma (96 cases with two primary melanomas, 15 with three, and 1 with four) were included into the study.
PubMedID- 22719794 This supports the theory that melanoma represent a family of tumors: rapidly growing melanomas with a high capacity to metastasize, on the one hand, and slowly growing lesions often detectable only after repeated follow-up visits, on the other.
PubMedID- 21835473 Conclusions: tumor-associated lymphangiogenesis seems to be associated with an increased risk of local recurrence, lymphatic spread, distant metastasis, and melanoma-related death in patients with conjunctival malignant melanomas.
PubMedID- 21852910 Since melanosis is often found in non-cutaneous melanoma patients, the origin of anorectal malignant melanoma might be the melanocytes in the squamous epithelium of the anal canal (18).
PubMedID- 25194935 Conclusions: dietary choices at the time of diagnosis are associated with melanoma-specific survival in patients with melanomas more than 1.00 mm thick.
PubMedID- 24406374 For instance, nodular melanomas (~15% of cutaneous melanoma) grow vertically from the beginning and present a necrotic core12.
PubMedID- 22570796 Recent data suggest multiple pathways of melanoma pathogenesis, with melanomas in sun-protected skin (trunk) developing in association with a high nevus count and intermittent ultraviolet radiation as opposed to those developing on sun-exposed skin in patients with low nevus counts and chronic sun exposure [17, 18].
PubMedID- 22367683 Oral melanoma represents 50% of all mucosal melanomas [5], and more than 20% of all melanomas of the head and neck region [9], 0.2% to 8% of the all the total cases of melanoma of the body [4], 1.6% of all head and neck malignancies [11], 1.3% of all cancers [8], and 0.5% of all oral malignancies [1, 4] in the world literature.

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