eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | medullary thyroid carcinoma |
| Comorbidity | C0027662|multiple endocrine neoplasia syndrome |
| Sentences | 2 |
| PubMedID- 26487970 | Acute coronary syndrome: a rare case of multiple endocrine neoplasia syndromes with pheochromocytoma and medullary thyroid carcinoma. |
| PubMedID- 22127824 | Thyroid neoplasia preclinical rodent studies with liraglutide have shown an increase in c-cell thyroid cancer, which so far has not been demonstrated in monkeys or humans.25 based on the preclinical studies in rodents, the fda has requested a boxed warning for liraglutide, which includes contraindications for use in “...patients with a personal or family history of medullary thyroid carcinoma (mtc) or in patients with multiple endocrine neoplasia syndrome type 2 (men 2).”25 recent findings from a large screening study in 5000 subjects treated with liraglutide did not support an effect of glp-1 receptor activation on serum calcitonin levels in humans, as reported in rodent studies.26 however, ongoing studies are evaluating the long-term safety of incretinbased therapy. |
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