eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | malignant peripheral nerve sheath tumor |
| Comorbidity | C0206728|plexiform neurofibromas |
| Sentences | 3 |
| PubMedID- 22084762 | Most nf1-associated mpnsts arise within preexisting plexiform neurofibromas; patients with nf1 therefore should be under lifetime surveillance for the development of mpnst [10]. |
| PubMedID- 25884485 | Given that we observed significant differences in the expression level of spp1 in mpnsts as compared with the benign plexiform neurofibromas and the fact that spp1 plays significant roles in both tumorigenesis and metastasis [33], we knocked down expression of the spp1 gene in four mpnst cell lines (st8814, s462, s1844.1 and s1507.2) and examined both the ability of these cell lines to form tumours (figure 3a) and the effect of knockdown on wound healing and invasion. |
| PubMedID- 20010302 | Neurofibromatosis type 1 patients with plexiform neurofibromas are at risk of developing malignant peripheral nerve sheath tumors. |
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