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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease malaria
Comorbidity C0024534|cerebral malaria
Sentences 9
PubMedID- 26445879 The sample collection was carried out from february 2005 to may 2007 and comprised 288 severe malaria children (130 with cerebral malaria and 158 with severe malaria but not cerebral malaria), 142 patients with uncomplicated malaria and 319 uninfected controls.
PubMedID- 22110393 In holoendemic transmission areas, sma is the primary clinical manifestation of severe childhood malaria, with cerebral malaria occurring only in rare cases.
PubMedID- 21707906 Severe malaria, including cerebral malaria (cm), is characterized by the sequestration of parasitized erythrocytes in the microvessels after cytoadherence to endothelial cells.
PubMedID- 21172048 The plasmodium converts arginine to ornithine and causes depletion in the host cell which is related to the human malarial hypoargininemia associated with cerebral malaria pathogenesis[18].
PubMedID- 25879828 Seventy five percent of complicated malaria cases were associated with cerebral malaria, 30% with acute kidney injury, 45% with hyperparasitaemia, 35% with schizontaemia and 35% with severe anaemia.
PubMedID- 23226502 The discovery cohort comprised of 367 malaria-positive children with either cerebral malaria (cm), severe malarial anemia (sma) or uncomplicated malaria (um), and 289 malaria-negative children who were either disease controls (dc) or community controls (cc) (table 1).
PubMedID- 22253622 Immune profiles were compared between malaria patients with (cerebral malaria) and without (including uncomplicated disease, asymptomatic plasmodium falciparum carriers) neurological symptoms.
PubMedID- 20931035 The manifestations of severe malaria include: cerebral malaria, severe anemia, hemoglobinuria, pulmonary edema or ards, abnormalities in blood coagulation and thrombocytopenia, cardiovascular collapse and shock, acute kidney failure, hyperparasitemia, metabolic acidosis and hypoglycemia.
PubMedID- 25858094 As a consequence, it was held that most malaria deaths were attributable to cerebral malaria and, thus, were primarily neurological in origin, with a smaller number resulting from severe malarial anaemia, which could be mitigated by an immediate blood transfusion.

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