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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease malaria
Comorbidity C0002871|anaemia
Sentences 49
PubMedID- 24194926 anaemia was independently associated with infections including malaria (or 3.49, 95% ci 1.78-6.82), hiv (or 2.17, 1.32-3.57) heavy hookworm infection (or 3.45, 1.73-6.91), low fruit consumption (or 1.55, 1.05-2.29) and being unmarried (or 1.37 , 95% ci 1.01-1.89).
PubMedID- 20433718 We compared anaemia rates in patients with malaria parasitaemia to that of patients without malaria parasitaemia.
PubMedID- 22548983 Nevertheless, malaria infection is associated with severe maternal anaemia, placental malaria and low birth weight – a risk factor for infant death [6,7].
PubMedID- 23553281 To the best of our knowledge, this is the second reported case of a patient affected by severe falciparum malaria with haemolytic anaemia that is likely associated with oral artemether-lumefantrine treatment.
PubMedID- 22624872 anaemia in malaria is caused by excessive removal of non-parasitized erythrocytes, the immune destruction of parasite-infected red cells, as well as by the impaired compensation due to bone marrow dysfunction [1,15,17,26-28].
PubMedID- 22708041 Severe malaria is associated with development of anaemia, usually normochromic and normocytic.
PubMedID- 21687688 In doing so, we adjust for malnutrition and the prevalence of infection of the major parasitic contributors and estimate the attributable risk of anaemia due to malnutrition, malaria, and helminth infections.
PubMedID- 25885648 malaria as aninfectious cause of anaemia is known to be associated with elevation and landsurface temperature.
PubMedID- 23226937 Asymptomatic malaria correlates with anaemia in pregnant women at ouagadougou, burkina faso.
PubMedID- 24490093 The mechanism of malaria associated with severe anaemia is multifactorial and include intensive haemolysis of circulating infected rbcs and noninfected erythrocytes due to glycosylphosphatidyl-inositol toxin release as wells as dyserythropoiesis due to cytokine effects and other inducers of inflammation such as haemozoin [13].
PubMedID- 20808923 Outpatient costs for both the health care provider and household directly were us$6.82 and us$7.76 for treating uncomplicated clinical malaria and malaria with anaemia respectively whilst the costs of inpatient care was us$39.36 for severe malaria alone and us$98.49 for malaria with severe anaemia.
PubMedID- 26464799 The factors associated with severe anaemia included unemployment of the parent, malaria parasitaemia and presence of sickle haemoglobin.
PubMedID- 24598692 Recent studies from west africa [15] and kenya [22], [23] estimate the proportion of anaemia attributable to malaria as approximately 15%.
PubMedID- 20559558 Although not part of this analysis, if we were to add the benefits of the additional health gains and subsequent cost savings from averting anaemia and those associated with averting the non-malaria admissions included in ‘all-cause’ hospitalisations (here we included only hospital admissions with parasitaemia), the icers would be even more cost effective.
PubMedID- 23978045 The use of epo in therapy has been recommended to alleviate anaemia due to malarial infections[11] and also in cerebral malaria management[12].
PubMedID- 22540175 In thailand, mixed infection with p. falciparum and p. vivax has been shown to attenuate the risk of severe anaemia associated with falciparum malaria – possibly due to some degree of cross-species immunity [70,160-162].
PubMedID- 21867566 Poor maternal and perinatal outcomes in cases of anaemia associated with malaria have recently been documented in some regions of sudan including kassala [19].
PubMedID- 22479564 Among anaemic children in malawi who were transfused for severe anaemia, 64% of them had malaria parasitaemia.
PubMedID- 24063858 Although these reported cases of late-onset haemolysis recovered without sequelae, and although anaemia is likely attributable to the malaria rather than to the use of iv artesunate [22], additional safety data are needed.
PubMedID- 20500831 The high prevalence of anaemia in malaria patients of the underweight status groups than those in the normal weight and overweight groups suggests malnutrition as a risk factor for anaemia besides malaria and helminth infections.
PubMedID- 21144084 The mild anaemia reported in 27% of the non-malaria infected children and some of the malaria-infected children may in part reflect poor nutritional status, background haemoglobinopathy, intestinal worm infestation and previous and/or repeated malaria infections in this area.
PubMedID- 21727667 Further studies are needed to explore the pathophysiology of anaemia in malaria cases in assam where expression of rbc complement receptors appears to be low even in normal healthy population.
PubMedID- 21687687 The authors attempt to partly address this challenge by computing the anaemia paf of malnutrition, malaria, and helminth infections.
PubMedID- 25950814 There were also other signs mentioned such as anaemia, dizziness, malaria that accounted for 19.7% during pregnancy, 16% during delivery and 10.2% during postpartum period (figures not shown in the table).
PubMedID- 24761799 anaemia associated with malaria is caused by hemolysis of the red blood cells and hypersplenism, a condition characterized by the exaggeration of inhibitory or destructive function of the spleen [15].
PubMedID- 22554203 The distribution of malaria subjects with anaemia (hb < 11 g/dl), thrombocytopaenia (platelet < 150,000/ul) or leucocytosis (>10,000/ul) were almost similar between the treatment groups (52.2% vs 47.8%, 71.6% vs 73%, 6% vs 5%).
PubMedID- 22484763 Furthermore, there are a number of causes of anaemia in malaria endemic areas, and whilst persistent malaria infection is a major factor there are other important contributory causes including co-infections with hiv-1 (davenport et al., 2010), and malnutrition.
PubMedID- 26101076 Among both fortification and non-fortification countries, hdi and malaria were significantly associated with anaemia (p,0.001).
PubMedID- 22727184 The overlap of severe anaemia with cerebral malaria and hyperpyrexia were 7.6% (11/145) and 12.4% (25/202) respectively (figure 4, table 2).
PubMedID- 21529344 Moreover, malaria often leads to severe anaemia in pregnant african women [10].
PubMedID- 21819616 Since our previous investigations in this region demonstrated that hiv-1 status [27] and bacterial co-infection [28] enhance the development of anaemia in children with malaria, all study participants were tested for these co-pathogens (testing methods listed below).
PubMedID- 23057857 In a logistic regression analysis, anaemia was significantly associated with malaria parasitaemia (aor=5.23, 95%ci[1.1-28.48]), sickle cell disorders (aor=2.89, 95%ci[1,32-6.34]), alpha-thalassemia (aor=1.82, 95%ci[1.2-3.35]), stunting (aor=3.37, 95%ci[1.93-5.88], age ranged from 2 to 4 years (aor=0.13, 95%ci[0.05-0.31]) and age > 5 years (aor=0.03, 95%ci[0.01-0.08]).
PubMedID- 22835018 Remarkably, anaemia was significantly associated with hiv-infection in malaria patients, and a trend towards a lower platelet number was also observed in co-infected individuals.
PubMedID- 21390301 Among these, 103 (11.9%) were recorded as malaria with severe anaemia (45% confirmed by microscopy) and 21 (2.4%) as cerebral malaria (57% confirmed by microscopy).
PubMedID- 25972443 Preventative strategies that target maternal health, recognising the importance of nutrition and vector-borne diseases such as malaria, a major cause of anaemia in malaria endemic regions, must also be prioritised.
PubMedID- 22429464 Overall prevalence of maternal malaria was 52%, associated with younger age, anaemia and smaller infant birth size.
PubMedID- 23593592 B19v and co-infection with b19v and malaria may be associated with microcytic anaemia rather than normocytic normochromic anaemia as seen in cases of b19v infection among persons with red cell abnormalities.
PubMedID- 24522135 The difference in levels of tnf alpha was significantly higher in falciparum malaria patients with anaemia, altered liver functions, hyperparasitemia, leucocytosis, hepatosplenomegaly and hypoglycaemia.
PubMedID- 24489732 The prevalence of anaemia was significantly associated with malaria infection (χ2 = 15.58, p<0.001) and s. haematobium infection (χ2 = 16.34, p<0.001).
PubMedID- 25138388 anaemia due to falciparum malaria in children has multifactorial pathogenesis, which includes suppression of bone marrow activity.
PubMedID- 24372186 Clinical course of acute haemolytic anaemia in children with malaria receiving an antimalarial containing dapsone (2·5 mg/kg/day for 3 d).
PubMedID- 21262115 Vivax malaria with auto-immune haemolytic anaemia (aiha) was diagnosed.
PubMedID- 25889709 It is estimated that approximately 500,000 pregnant women develop severe anaemia due to falciparum malaria [31,32] and up to 10,000 maternal anaemia-related deaths are as a result of malaria infection in sub-saharan africa [33,34].
PubMedID- 20359364 anaemia in malaria can be associated with more pathogenetic mechanisms, such as haemolysis and dyserythropoiesis.
PubMedID- 21304925 It is likely that the fraction of anaemia attributable to malaria differs between settings and this fraction is likely to be lower in areas with lower transmission intensity such as senegal.
PubMedID- 25889165 The pathogenesis of severe anaemia in vivax-malaria remains unclear and is likely caused by multiple underlying factors.
PubMedID- 20712868 Monocyte icam-1 levels are higher in cerebral malaria patients compared with severe malaria anaemia patients.
PubMedID- 26425794 Results: in the overall study population, malaria was strongly associated with anaemia (or = 6.83, 95% ci: 2.90-16.05), but population impact was modest (population-attributable fraction = 2.5%).
PubMedID- 24289142 The anaemia in malaria-positive groups was presented in 70.9% of the cases: this anaemia could be divided into 35.6% of anaemia cases caused by unknown reason, as occurred in the malaria-negative groups, and into 35.3% of anaemia attributed to malaria.

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