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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease macular degeneration
Comorbidity C0456909|blindness
Sentences 26
PubMedID- 24801942 Monogenic as well as complex rpe-related diseases, such as age-related macular degeneration, are common causes of blindness while therapeutic options are limited (lim et al.
PubMedID- 22882737 Currently, it is well established that a deregulated and persistent angiogenesis is one of the hallmarks of cancer 10,11. furthermore, there is overwhelming evidence on the involvement of deregulated angiogenesis in many other pathological situations, which are currently described as angiogenesis-dependent diseases 12. the interest and impact of angiogenesis as a new therapeutical target from the treatment of non-oncological angiogenesis-dependent diseases is well represented by the recent concession of the lasker-debakey clinical medical research award 2010 to dr. napoleone ferrara for the discovery of vegf as a major mediator of angiogenesis and the development of an effective anti-vegf therapy for wet macular degeneration, a leading cause of blindness in the elderly 13. this is a type of age-related macular degeneration, included as a rare disease in the orphanet website with the orpha number orpha279.
PubMedID- 26260587 In the eye, choroidal neovascularization (cnv) causes blindness in patients with age-related macular degeneration (amd).
PubMedID- 20846177 Not surprisingly, rpe cell damage is a major cause of human blindness worldwide, with age-related macular degeneration a prevalent example.
PubMedID- 22938801 Lutein, the primary carotenoid present in the central area of the retina of eye appears to be associated with the protection against age-related macular degeneration (the leading cause of blindness in older adults).
PubMedID- 20887885 This year's lasker debakey clinical research award goes to napoleone ferrara for the discovery of vascular endothelial growth factor (vegf) as a major mediator of angiogenesis and for the development of an effective anti-vegf therapy for wet macular degeneration, a leading cause of blindness in the elderly.
PubMedID- 22754971 Since 2005, patients and their ophthalmologists have faced a dilemma in treating age-related macular degeneration (amd)--the leading cause of blindness in the united states.
PubMedID- 24868138 There are also indications that type vi collagen assemblies are associated with eye disorders, such as age-related macular degeneration, the leading cause of blindness in the western world, and sorsby's fundus dystrophy [37,38].
PubMedID- 24169698 Lipofuscin accumulation in retinal pigment epithelial (rpe) cells of the eye implicates the etiologies of stargardt disease and age-related macular degeneration, a leading cause of blindness in the elderly.
PubMedID- 22664333 In therapeutic dosages, zinc has been used for the treatment of acute diarrhea in infants and children, common cold, wilson's disease, sickle cell disease and for prevention of blindness in patients with age related macular degeneration.
PubMedID- 26307969 macular degenerations represent leading causes of central blindness or low vision in developed countries.
PubMedID- 24358235 Dicer is decreased in geographic atrophy (ga), a form of age-related macular degeneration leading to blindness [40].
PubMedID- 22801846 Impact of availability of anti-vascular endothelial growth factor therapy on visual impairment and blindness due to neovascular age-related macular degeneration.
PubMedID- 23132794 Retinitis pigmentosa, other inherited retinal diseases, and age-related macular degeneration lead to untreatable blindness because of the loss of photoreceptors.
PubMedID- 24479434 We reviewed published population-based data from ssa and other relevant populations on the leading psed, specifically glaucoma, diabetic retinopathy and age-related macular degeneration, as causes of blindness and visual impairment in adults.
PubMedID- 22590627 Dysfunction and death of retinal pigment epithelium (rpe) constitute the final common pathway in age-related macular degeneration, the leading cause of legal blindness among the elderly (reviewed by binder et al.
PubMedID- 26472075 For example, quantitative cell imaging is potentially a powerful tool for qualifying cell therapy products such as those that can cure macular degeneration, the leading cause of blindness in adults (7 million us patients, gross domestic product loss $30 billion [2]).
PubMedID- 23627893 Introduction: glaucoma is one of the major causes of blindness, affecting together with age-related macular degeneration > 70 million people worldwide.
PubMedID- 24955576 Specific testing will be required to understand the mechanisms involved and to establish whether there is clinical potential in combining neuroprotectants, to improve the quality of life of people affected by retinal pathology, such as age-related macular degeneration, the major cause of blindness and visual impairment in older adults.
PubMedID- 22281388 Methods: we started two prospective clinical studies to establish the safety and tolerability of subretinal transplantation of hesc-derived retinal pigment epithelium (rpe) in patients with stargardt's macular dystrophy and dry age-related macular degeneration--the leading cause of blindness in the developed world.
PubMedID- 21437192 The first trial is for the treatment of advanced stargardt's macular dystrophy, a form of juvenile macular degeneration that often leads to blindness, and the second trial is for dry age-related macular degeneration.
PubMedID- 24319332 Age-related macular degeneration, a common cause of blindness after the age of 65, is characterized by either the presence of drusen (dry amd) or vegf-induced choroidal endothelial cell proliferation with associated leakage (wet exudative form of amd) [13].
PubMedID- 23521856 Aging contributes to the appearance of several retinopathies and is the largest risk factor for aged-related macular degeneration, major cause of blindness in the elderly population.
PubMedID- 24450440 Photodynamic therapy is also used in ophthalmology [2] and for many years pdt was the mainstay for treating exudative age-related macular degeneration, the main cause of blindness in the aged western population [3].
PubMedID- 24759774 A good example is age related macular degeneration, the leading cause of blindness in the u.k [1].
PubMedID- 24982737 Dysfunctional rpe is believed to be an underlying pathological condition in age-related macular degeneration, a leading cause of blindness in the elderly in developed countries.

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