eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | lysosomal acid lipase deficiency |
| Comorbidity | C0004153|atherosclerosis |
| Sentences | 2 |
| PubMedID- 26225414 | The morbidity of late-onset cesd results from atherosclerosis (coronary artery disease, stroke), liver disease (e.g., altered liver function +/- jaundice, steatosis, fibrosis, cirrhosis and related complications of esophageal varices, and/or liver failure), complications of secondary hypersplenism (i.e., anemia and/or thrombocytopenia), and/or malabsorption. |
| PubMedID- 25699256 | Although rhlal treatment seems to be a viable therapeutic strategy for premature atherosclerosis in cesd patients, it is unclear what the effects would be of rhlal treatment in patients having atherosclerosis unrelated to a deficiency in lal. |
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