eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | lynch syndrome |
| Comorbidity | C1527249|colorectal cancers |
| Sentences | 8 |
| PubMedID- PMC3288925 | Msi is present in 80-85% of colorectal cancers associated with lynch syndrome. |
| PubMedID- 25583420 | Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum. |
| PubMedID- 21132538 | colorectal cancers associated with the hereditary nonpolyposis colorectal cancer (hnpcc) syndrome are characterized by wide-spread microsatellite instability, but show few gross genomic alterations. |
| PubMedID- 22262812 | colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function. |
| PubMedID- 20704743 | About 3% of all colorectal cancers is due to lynch syndrome, an autosomal dominant condition caused by germline mutations in one of the dna mismatch repair (mmr) genes, mlh1, msh2, msh6 and pms2 [1]. |
| PubMedID- 25794514 | Approximately 3% of colorectal cancers are associated with lynch syndrome. |
| PubMedID- PMC2876284 | This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype. |
| PubMedID- 23245329 | Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways. |
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