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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease lynch syndrome
Comorbidity C0007113|rectal cancer
Sentences 45
PubMedID- 20495877 Magnetic resonance colonography for colorectal cancer screening in patients with lynch syndrome gene mutation.
PubMedID- 26249337 Lower prevalence of lynch syndrome in colorectal cancer patients in a japanese hospital-based population.
PubMedID- 20206180 One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome.
PubMedID- 20303416 We reviewed an integrated electronic health record (ehr) to determine diagnostic evaluation for lynch syndrome in patients diagnosed with colorectal cancer (crc).
PubMedID- 20010342 Prevention of metachronous colorectal cancer in patients with lynch syndrome.
PubMedID- 22262812 Colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function.
PubMedID- 23073952 Identification of lynch syndrome among patients with colorectal cancer.
PubMedID- 25794514 Approximately 3% of colorectal cancers are associated with lynch syndrome.
PubMedID- 25142628 The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with lynch syndrome (4%).
PubMedID- 20704743 About 3% of all colorectal cancers is due to lynch syndrome, an autosomal dominant condition caused by germline mutations in one of the dna mismatch repair (mmr) genes, mlh1, msh2, msh6 and pms2 [1].
PubMedID- 23733757 Purpose: molecular screening techniques are available to identify hereditary lynch syndrome in people with newly diagnosed colorectal cancer (crc).
PubMedID- 23073955 lynch syndrome in patients with colorectal cancer: finding the needle in the haystack.
PubMedID- 25583420 Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum.
PubMedID- 25816162 However, a higher frequency of mmr-dcf was observed in lynch syndrome patients with distal colorectal cancer localisation.
PubMedID- PMC3288925 Msi is present in 80-85% of colorectal cancers associated with lynch syndrome.
PubMedID- 24225971 Molecular tumor testing for lynch syndrome in patients with colorectal cancer.
PubMedID- 25910169 The objective of this project was to estimate the cost–utility of strategies to identify lynch syndrome in individuals with early-onset colorectal cancer in the nhs.
PubMedID- 25213040 Aim: colonic surveillance reduces the lifetime risk of colorectal cancer in patients with lynch syndrome (hereditary nonpolyposis colorectal cancer) from 60 to 80% to 10% and confers a 7-year survival advantage.
PubMedID- 24415879 Epithelial-mesenchymal transition in colorectal cancer tissue of patients with lynch syndrome.
PubMedID- 23125224 Cell cycle-related genes as modifiers of age of onset of colorectal cancer in lynch syndrome: a large-scale study in non-hispanic white patients.
PubMedID- PMC2876284 This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype.
PubMedID- 23245329 Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways.
PubMedID- 26064726 Our findings emphasize the importance of considering the possibility of lynch syndrome in pregnant women with colorectal cancer, particularly those with a family history of this condition.
PubMedID- 22411104 Daily aspirin reduces colorectal cancer incidence in patients with lynch syndrome.
PubMedID- 21768580 Strategies to identify the lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.
PubMedID- 23598716 Purpose: routine screening for evidence of dna mismatch repair abnormalities can identify colorectal cancer patients with lynch syndrome, but impact in usual care settings requires study.
PubMedID- 23508345 The surgical management of the lynch syndrome patient with colorectal cancer needs to be individualized.
PubMedID- 22175017 However, there have been fewer studies on endometrial cancer compared to colorectal cancer in patients with lynch syndrome.
PubMedID- 25323653 Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for lynch syndrome in adults with colorectal cancer.
PubMedID- 23896635 Although variable, the lifetime risk of developing colorectal cancer (crc) in patients with lynch syndrome is approximately 80 %, with male carriers having a higher cumulative risk than female carriers [2].
PubMedID- 21159521 Perspectives for tailored chemoprevention and treatment of colorectal cancer in lynch syndrome.
PubMedID- 22480969 Background: recommended strategies to screen for lynch syndrome in colorectal cancer are not applied in daily practice and most of lynch cases remain undiagnosed.
PubMedID- 21743847 The american college of gastroenterology found moderate quality evidence for their recommendation that colorectal cancer patients with lynch syndrome undergo colonoscopy every 2 years beginning at age 20-25 and then annually after age 40 [9].
PubMedID- 26473097 Testing for lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives.
PubMedID- 22056658 Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer.
PubMedID- 21132538 Colorectal cancers associated with the hereditary nonpolyposis colorectal cancer (hnpcc) syndrome are characterized by wide-spread microsatellite instability, but show few gross genomic alterations.
PubMedID- 23470269 Background: colorectal cancer (crc) associated with lynch syndrome usually presents at a relatively young age.
PubMedID- 22549751 Objective: to define the neoplastic risk in the remaining colon after proctectomy for rectal cancer in patients with hereditary nonpolyposis colorectal cancer (hnpcc).
PubMedID- 25754680 Fertility after young-onset colorectal cancer: a study of subjects with lynch syndrome.
PubMedID- 25534380 Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis.
PubMedID- 19957108 Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with lynch syndrome.
PubMedID- 24056992 Some studies reported since publication of the egapp analysis have added to the evidence regarding clinical utility to the relatives of colorectal cancer patients diagnosed with lynch syndrome.
PubMedID- 26284327 The lifetime risk of colorectal cancer for males with lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females.
PubMedID- 22237445 Implementing screening for lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.
PubMedID- 25081898 Background: recognising colorectal cancer (crc) patients with lynch syndrome (ls) can increase life expectancy of these patients and their close relatives.

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