eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0242379|lung cancer |
| Sentences | 14 |
| PubMedID- 23317414 | Present report evaluated the association of polymorphism in exon 4 arg72pro (g>c) of the p53 gene with lung cancer susceptibility using 175 cancer cases and 202 controls from the north indian population. |
| PubMedID- 24369748 | Associations of tp53 rs2078486 with lung cancer among different subgroups with different age, gender, smoking status, alcohol and tea drinking status, indoor air pollution exposure and histo-pathological types of lung cancer. |
| PubMedID- 20381264 | Purpose: the aim of this study was to clarify the effects of nitric oxide (no) on radiation-induced cell killing and chromosome aberrations in two human lung cancer cell lines with a different p53 gene status. |
| PubMedID- 24955217 | Taken together, our results indicate that ikkα or ikkβ inhibition therapy might prove to be a promising approach to be validated in clinical trials, particularly using combination strategies to treat kras-induced lung cancer with loss of the tumor suppressor p53. |
| PubMedID- 22510280 | Notably, a novel gene csmd3 was identified as the second most frequently mutated gene (next to tp53) in lung cancer. |
| PubMedID- 22008105 | [high resolution melting analysis for detecting p53 gene mutations in patients with non-small cell lung cancer]. |
| PubMedID- 25398693 | In addition, we used lung cancer cell lines with different p53 gene background (p53 null and p53 wild-type). |
| PubMedID- 21435097 | However, the frequency of the hif1a c1772t variant allele was significantly higher in lung cancer patients with tp53 loh (p = 0.015). |
| PubMedID- 24548782 | Recently, csmd3 was identified as the second most frequently mutated gene (next to tp53) in lung cancer, where it was demonstrated that loss of csmd3 results in increased proliferation of airway epithelial cells [24]. |
| PubMedID- 22524618 | Methods: dld-1 cells (a human colorectal cancer cell line) and h1299 cells (a non-small cell lung cancer cell line) with differences of p53 gene status were used. |
| PubMedID- 25594032 | In this study, we identified the pict1 protein expression profile in non-small cell lung cancer (nsclc) with wild-type tp53 in the nucleolus and cytoplasm, and revealed the relationship between pict1 expression and patient clinicopathological factors. |
| PubMedID- 21129811 | This study was conducted to identify genetic factors predisposing to tp53 mutations in patients with non-small cell lung cancer (nsclc). |
| PubMedID- 23341789 | To examine whether su1124 induced different cell death depending on the p53 status, we used various lung cancer cells with different p53 gene statuses. |
| PubMedID- 25047674 | Egfr-mutated lung cancer in li-fraumeni syndrome. |
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