eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0025149|medulloblastoma |
| Sentences | 3 |
| PubMedID- 22736505 | Here, we demonstrate that genistein inhibits the growth of glioblastoma multiforme and medulloblastoma cells with different tp53 mutations and radio-responses by arresting the cells at g2/m phase of the cell cycle. |
| PubMedID- 24139898 | In contrast, the medulloblastoma genome of this li-fraumeni syndrome case is one of the strongest x hypermutated samples in our data set (figure 7e). |
| PubMedID- 24231268 | Based on these observations and previous work where we demonstrated that pharmacologically inhibiting mdm2 in medulloblastoma cells with wildtype tp53 reactivated p53 activity, it may be advantageous to investigate possible synergies between jq1 and mdm2 inhibitors, such as nutlin-3 [32]. |
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