eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0007131|nsclc |
| Sentences | 3 |
| PubMedID- 25594032 | We scrutinized pict1 expression in samples of nsclc with wild-type tp53, and showed a correlation between cytoplasmic pict1 expression and several clinicopathological factors in these patients. |
| PubMedID- 24763730 | To experimentally address this limitation and to examine the brms1 specific effects in regulating cell migration and invasion, we chose to exploit two established genetic alterations observed in human nsclc - the loss of the p53 tumor suppressor and gain-of function mutation in the k-ras allele [16]. |
| PubMedID- 21331359 | Most clinical studies suggest that nsclc with tp53 alterations carries a worse prognosis and may be relatively more resistant to chemotherapy and radiation. |
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