eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | li-fraumeni syndrome |
| Comorbidity | C0004114|astrocytomas |
| Sentences | 2 |
| PubMedID- 20714900 | Interestingly, all five examined astrocytomas of patients with li-fraumeni syndrome carried r132c idh1 mutations, indicating that glial/glioma precursor cells with a germline tp53 mutation carry an increased risk to acquire such a non-r132h mutation [130]. |
| PubMedID- 22313596 | In that study, 92% of who grade ii astrocytomas with tp53 mutation recurred and 57% progressed to higher grades, whereas 64% without tp53 mutation experienced recurrence and 41% had malignant progression. |
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