eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | kennedy disease |
| Comorbidity | C0024530|malaria |
| Sentences | 6 |
| PubMedID- 23825944 | Dc8 and dc13 var genes associated with severe malaria bind avidly to diverse endothelial cells. |
| PubMedID- 24353315 | Plasmodium falciparum, the parasite causing cerebral malaria, exhibits monoallelic expression of the var gene family, which encodes variants of the p. falciparum erythrocyte membrane protein 1 (9). |
| PubMedID- 21674009 | It has been suggested, on the basis of studies conducted in tanzania and papua new guinea, that expression of group a or b/a var genes are associated with severe children malaria, while group c var genes are linked to asymptomatic malaria. |
| PubMedID- 22533832 | The overall conclusion from these studies is that members of the upsa var genes are associated with severe malaria in children. |
| PubMedID- 25786326 | Recently, domain cassettes 8 and 13 encoded by var genes that are associated with severe malaria were identified [18]. |
| PubMedID- 22461905 | While it is possible that at the onset of switching activation of upsa var genes could lead to severe malaria in the absence of immunity by cytoadhesive selection. |
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