eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | iga nephropathy |
| Comorbidity | C0403447|chronic renal insufficiency |
| Sentences | 1 |
| PubMedID- 21422741 | Many lessons have been learnt from this experimental model; importantly, that glomerular hyperfiltration, hyperfusion, hypertension, and hypertrophy are associated with the progression of glomerulosclerosis.4,5) other experimental models of progressive glomerulonephrits, such as the accelerated form of anti-glomerular basement membrane nephritis characterized by destructive or crescentic glomerular lesions, differ substantially from the pathohistological features of the gradually accumulating mesangial matrix seen in human diabetic nephropathy and iga nephropathy, eventually leading to chronic renal insufficiency. |
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