eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hypothyroidism |
| Comorbidity | C0034013|precocious puberty |
| Sentences | 3 |
| PubMedID- 24251145 | Van wyk and grumbach first reported multicystic ovaries with precocious puberty in patients with hypothyroidism in 1960. |
| PubMedID- 23329774 | Van wyk-grumbach syndrome is a rare disease characterized by precocious puberty associated with prolonged hypothyroidism and multicystic enlarged ovaries. |
| PubMedID- 23901203 | The clinical syndrome of severe primary hypothyroidism associated with isosexual precocious puberty in females was first described by kendle in 1905. |
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