eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hypothyroidism |
| Comorbidity | C0028754|obesity |
| Sentences | 9 |
| PubMedID- 21335378 | Although patients and lay individuals almost immediately associate hypothyroidism with obesity, the incidence of hypothyroidism in obese individuals is not increased, and changes in body composition during the transition from severe hypothyroidism to mild thyrotoxicosis are meager (9–11). |
| PubMedID- 23351558 | Our exclusion criteria were defined as: heavy smokers (more than twenty cigarettes per day); alcohol consumption; pregnancy; recent surgery, patients with coronary heart disease; known cases of diabetes mellitus; patients with proven malignancy, asthma, chronic cough, chronic inflammatory disease and psychological problems; history of chronic kidney and liver disease, obesity due to endocrine disease (hypothyroidism or uncontrolled thyroid disease); and genetic obesity syndrome. |
| PubMedID- 23051081 | hypothyroidism was associated with obesity and perturbations in lipid profile particularly increase in total cholesterol, c-ldl, apob, apob/apoa1 and lp(a) and decrease in apoa1 and c-hdl. |
| PubMedID- 24872812 | Several studies have suggested a role for obesity in the development of thyroid insufficiency in the tissue based on reduced expression of t3 and tsh receptors in the fat of obese subjects [25]. |
| PubMedID- 26511212 | Untreated or sub-clinical hypothyroidism is associated with insulin resistance, obesity, adverse effects on cardiovascular system, hypertension and in turn risk of nephropathy. |
| PubMedID- 23564558 | Osas frequency is likely to increase in hypothyroidism because of obesity, macroglossia, dysfunctional upper respiratory tractus (urt) musculature, deposition of mucopolysaccharides in urt tissues, and decreased ventilatory control. |
| PubMedID- 24971238 | Subjects < 30 or > 60 years of age and pregnant women, and those with chronic renal failure, infection, inflammation, diabetes mellitus type 2, hyperlipidemia, thyroid function disorders, secondary obesity (due to hypothyroidism or cushing syndrome), and some chronic illnesses were excluded. |
| PubMedID- 26004610 | Objective: obesity has been associated with hypothyroidism and cardiac autonomic dysfunction. |
| PubMedID- 24251274 | [3031] however, obesity in hypothyroidism is not primarily due to excess adiposity as increase in bodyweight in thyroid deficiency state is mostly due to accumulation of water and mucopolysaccharides in subcutaneous tissues. |
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