eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hypothyroidism |
| Comorbidity | C0020443|hypercholesterolemia |
| Sentences | 4 |
| PubMedID- 24288742 | The combination of hypercholesterolemia with hypothyroid status caused more pronounced changes in the lipid spectrum and atherogenic index and more pronounced lytic and necrobiotic changes in cardiomyocytes. |
| PubMedID- 25778649 | hypercholesterolemia in hypothyroid rats (thyroxine concentration 2-fold below the normal) was paralleled by a pronounced increase of the concentration of free circulating extracellular dna and total matrix metalloproteinases 2 and 7 activity. |
| PubMedID- 22205844 | Overt thyroid disease is associated with atherosclerotic cardiovascular disease; this is an unambiguous sign of overt hypothyroidism [7,8] and results from hypercholesterolemia and elevated blood pressure. |
| PubMedID- 24396699 | Prescription of statins in patients with hypercholesterolemia associated with undetected hypothyroidism may cause severe rhabdomyolysis via additive interaction as shown in this case. |
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