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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hyperuricemia
Comorbidity C0948265|metabolic syndrome
Sentences 20
PubMedID- 22095983 Objective: hyperuricemia is common in patients with metabolic syndrome.
PubMedID- 25356596 In addition to the morbidity that is attributable to gout, hyperuricemia is also associated with metabolic syndrome, hypertension, and cardiovascular disease.
PubMedID- 22701608 Additionally, hyperuricemia has been associated with metabolic syndrome and implicated as a risk factor in the etiology of hypertension, atherosclerosis, insulin resistance and diabetes [3], [4].
PubMedID- 24527421 hyperuricemia is associated with metabolic syndrome as well as gout, and the prevalence of hyperuricemia is increasing in korea.
PubMedID- 23804456 High uricemia in humans may protect against oxidative stress, but hyperuricemia also associates with the metabolic syndrome, and urate and uric acid can crystallize to cause gout and renal dysfunctions.
PubMedID- 22712045 The higher serum uric acid level of hyperuricemia has been associated with metabolic syndrome in studies of health screenees [3,6-9] and in nationwide surveys [10,11].
PubMedID- 24020339 Gout and hyperuricaemia are associated with the metabolic syndrome, diabetes mellitus, obesity and hypertension.
PubMedID- 24472219 The adjusted odds ratio for metabolic syndrome of the hyperuricemia group increased significantly to 1.787 (1.125–2.839) compared with the healthy group.
PubMedID- 23441715 Furthermore, arginase inhibition significantly reduced hyperinsulinaemia and hypertriglyceridaemia without affecting hyperuricaemia or hypercholesterolaemia associated with metabolic syndrome.
PubMedID- 25763281 Some authors consider hyperuricemia in metabolic syndrome to be the consequence of elevated serum insulin levels, which have been shown to stimulate renal reabsorption of uric acid.
PubMedID- 20158446 Background: hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease.
PubMedID- 22615932 There is evidence that hyperuricemia is associated with the metabolic syndrome [1], [2] and incident type 2 diabetes [3], [4].
PubMedID- 26004548 Conclusions: it can be concluded that hyperuricemia is strongly associated with metabolic syndrome.
PubMedID- 21694941 The close association of hyperuricemia with metabolic syndrome, hypertension and renal insufficiency ensures that nephrologists will see increasing numbers of gout-afflicted patients.
PubMedID- 26064845 hyperuricemia has attributed to hyperinsulinemia in metabolic syndrome and decreased excretion of uric acid causing endothelial dysfunction in kidney leads to renal disease and cardiovascular disorders.
PubMedID- 26141680 Objectives: to investigate the influence of mets (metabolic syndrome) in combination with hyperuricemia on left ventricular hypertrophy (lvh) in residents in the rural area of northeast china.
PubMedID- 22011411 hyperuricemia is present in patients with the metabolic syndrome (2) and in subjects with insulin resistance (3).
PubMedID- 21346177 Most authorities have viewed the presence of hyperuricemia in metabolic syndrome as a secondary response to obesity and hyperinsulinemia and have attributed this to the effects of insulin on proximal tubular urate transport (8), the effect of elevated leptin (9), or altered purine metabolism (10).
PubMedID- 23966810 We evaluated the combination effect of the alkalizer citrate with the xanthine oxidase inhibitor allopurinol on renal function and uric acid in patients with hyperuricemia associated with obesity and/or metabolic syndrome (mets), who were extracted from among the subjects enrolled in a prospective randomized controlled study aimed at assessing the efficacy of such a combination for improving renal function.
PubMedID- 23588856 hyperuricemia has been attributed to hyperinsulinemia in metabolic syndrome and to decreased uric acid excretion in kidney dysfunction, and is not acknowledged as a main mediator of metabolic syndrome, renal disease, and cardiovascular disorder development.

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