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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hyperuricemia
Comorbidity C0011881|diabetic nephropathy
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PubMedID- 22701621 In this study, we used streptozotocin (stz)-induced diabetic nephropathy model with hyperuricemia and dyslipidemia in rats, and found over-expression of renal inflammasome components nlrp3, apoptosis-associated speck-like protein and caspase-1, resulting in elevation of il-1beta and il-18, with subsequently deteriorated renal injury.

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