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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hyperthermia
Comorbidity C0010674|cystic fibrosis
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PubMedID- 22777528 Study question: does elevated temperature-induced cystic fibrosis transmembrane conductance regulator (cftr) down-regulation in sertoli cells in cryptorchid testis disrupt testicular tight junctions (tjs) through the nuclear factor kappa b (nf-kappab)/cyclooxygenase-2 (cox-2)/prostaglandin e(2) (pge(2)) pathway.

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