eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hyperprolactinemia |
| Comorbidity | C0032000|pituitary adenoma |
| Sentences | 4 |
| PubMedID- 20963563 | Patients were divided into three groups according to treatment outcomes and pathologic results: (a) prolactinoma that responded to dopamine agonist (da) treatment (prda); (b) prolactinoma requiring surgical treatment (prs); and (c) non-functioning pituitary adenoma with hyperprolactinemia (nfpah). |
| PubMedID- 22418404 | hyperprolactinemia in a patient with a pituitary adenoma receiving antipsychotic drug therapy. |
| PubMedID- 19551516 | Occasionally, multifocal polyclonal pituitary adenomas associated with hyperprolactinemia may arise either due to extrinsic changes in hypothalamic factors, or to pituitary stalk compression, blocking lactotroph inhibition by dopamine [27]. |
| PubMedID- 25045522 | Learning points: hypopituitarism may be the presenting symptom of lymphoma in the absence of associated overt symptoms or signs of a haematological malignancy resulting in delay in diagnosis and institution of treatment.pituitary dysfunction due to tumour infiltration has a greater tendency to involve the posterior pituitary and infundibulum resulting in diabetes insipidus and hyperprolactinaemia compared with a non-functioning pituitary adenoma.the common associated symptoms of hypopituitarism due to lymphoma infiltration of the hypothalamic-pituitary system include painful ophthalmoplegia, cranial nerve palsies and constitutional symptoms.radiological abnormalities of the hypothalamic-pituitary region are usually present and often associated with cavernous sinus or stalk involvement.with early institution of definitive treatment, both haematological response and improvement of pituitary dysfunction are expected although the reversal of hypopituitarism tends to be partial and delayed.a high index of suspicion of underlying malignancy such as lymphoma should be present in patients presenting with acute pituitary dysfunction associated with painful ophthalmoplegia, radiological features atypical of pituitary adenomas and constitutional symptoms to enable early diagnosis and prompt initiation of definitive therapy. |
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