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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hyperparathyroidism
Comorbidity C0020437|hypercalcemia
Sentences 46
PubMedID- 23330456 Cinacalcet is also expected to be useful in the treatment of intractable hypercalcemia in patients with primary hyperparathyroidism for whom parathyroidectomy is indicated but surgery is clinically inappropriate or contraindicated.
PubMedID- 23026597 Conclusions: cinacalcet is an effective alternative for the treatment of hypercalcemia in patients with persistent hyperparathyroidism after kt.
PubMedID- 21151209 Diagnosis: severe persistent hyperparathyroidism associated with mild hypercalcemia following renal transplantation.
PubMedID- 20191460 It has long been thought that parathyroidectomy was the only way to solve the problem of stabilized hypercalcemia associated with moderate-severe persistent hyperparathyroidism after kidney transplant.
PubMedID- 25861621 hypercalcemia associated with hyperparathyroidism is a common complication after kidney transplantation [1].
PubMedID- 23198183 A 71 yo woman with primary hyperparathyroidism awaiting surgery because of significant hypercalcemia and hypercalciuria presented to the local emergency department with the chief complaints of discomfort in her neck, sore throat, and difficulty swallowing.
PubMedID- 21112866 Although the safety and efficacy of this drug in treating hypercalcemia associated with hyperparathyroidism have not yet been established in clinically controlled trials, its off-label use is not uncommon.
PubMedID- 24251127 We describe a case of hyperparathyroidism with concomitant hypercalcemia accompanied by central pontine myelinosis without hyponatremia/hyperosmolality or associated rapid corrections of sodium, which developed as a consequence of severe hypokalaemia.
PubMedID- 21887663 Based on laboratory tests and ultrasound imaging, acute pancreatitis with hypercalcemia due to tertiary hyperparathyroidism was diagnosed.
PubMedID- 24251162 Acute pancreatitis due to hypercalcemia associated with hyperparathyroidism (hpt) is not very common.
PubMedID- 22876055 Patients with secondary or tertiary hyperparathyroidism, or other causes of hypercalcemia such as malignancy, vitamin d intoxication, immobilization, medications, hyperthyroidism, and other endocrine diseases, were excluded.
PubMedID- 20145928 If left untreated, hyperparathyroidism can lead to symptoms of hypercalcemia, renal complications, and bone disease connected to hyperparathyroidism, which is characterized by high turnover and remodeling rates leading to osteoporosis and increased fracture risk.
PubMedID- 22431942 Functional parathyroid cyst: a rare cause of malignant hypercalcemia with primary hyperparathyroidism-a case report and review of the literature.
PubMedID- 26442164 We report a 60-year-old female patient manifesting hypercalcemia due to hyperparathyroidism, a solitary fibrous tumor (sft) of the pleura, multiple gastrointestinal stromal tumors (gists), and moyamoya disease associated with nf1.
PubMedID- 21394466 Elevated pth values may also persist in some patients and hypercalcemia, in combination with hyperparathyroidism, has been traditionally considered a sign of autonomous pth secretion and an indication for parathyroidectomy in transplant recipients [16, 17].
PubMedID- 26239247 Those with elevated pth level were assumed to have pth-mediated hypercalcemia (the majority of which had primary hyperparathyroidism or php).
PubMedID- 25755881 More than 90% of cases of hypercalcemia are due to primary hyperparathyroidism or malignancy.
PubMedID- 21286893 A case of acute pancreatitis as a first symptom of primary hyperparathyroidism with severe hypercalcemia is reported.
PubMedID- 24302625 Thus, adult male and female crh−120/+ mice, aged 8–12 weeks, were hypercalcemic (table 1), and this was associated with significantly reduced plasma pth concentrations (table 1), indicating that the hypercalcemia was not due to hyperparathyroidism associated with parathyroid tumors.
PubMedID- 26019872 A de novo heterozygous inactivating mutation of calcium-sensing receptor (casr) gene typically causes neonatal hyperparathyroidism (nhpt) with moderate hypercalcemia and hyperparathyroid bone disease.
PubMedID- 23202713 When diagnosing anterior mediastinal tumor with hypercalcemia, atypical carcinoid of thymus with hyperparathyroidism should be considered.
PubMedID- 25926120 The presence of isolated primary hyperparathyroidism, as a cause of hypercalcemia in cancer patients, has been described in approximately 5-10% of the patients.
PubMedID- 24251163 On follow-up she is diagnosed to have primary hyperparathyroidism with hypercalcemia due to left inferior parathyroid adenoma which improved with intravenous (iv) zolindronic acid therapy and now she is planned to undergo parathyroidectomy.
PubMedID- 23146456 Persistent hyperparathyroidism associated with hypercalcemia and hyperphosphatemia have been associated with poor graft and patient survivals.
PubMedID- 23146463 Background: cinacalcet is an effective treatment for hypercalcemia due to persistent hyperparathyroidism (hpt) in patients who have undergone kidney transplantation (kt).
PubMedID- 24736693 Great majority of patients with severe hypercalcemia is attributable to either primary hyperparathyroidism or malignancy.
PubMedID- 23799171 Because the serology and imaging tests were only suggestive of hypercalcemia due to hyperparathyroidism, the patient was referred to the ent department where the diagnosis of primary hyperparathyroidism with osteitis fibrosa cystica due to a parathyroid tumor was considered.
PubMedID- 21078161 Parathyroid carcinoma (pc) is a rare cause of primary hyperparathyroidism with characteristic marked hypercalcemia and highly elevated parathyroid hormone levels.
PubMedID- 24334568 Metastatic calcification occurs in the setting of hypercalcemia, most commonly attributable to hyperparathyroidism, often secondary to renal dysfunction.
PubMedID- 22577545 In addition to the previous mechanism, several other factors like uremic toxins, increased circulating endogenous nos inhibitors like asymmetric dimethylarginine, secondary hyperparathyroidism leading to hypercalcemia, and increased expression of endothelin a receptors have also been implicated in the pathogenesis of hypertension in ckd.
PubMedID- 25741940 Antenatal bartter syndrome presenting as hyperparathyroidism with hypercalcemia and hypercalciuria: a case report and review.
PubMedID- 25505684 hypercalcemia associated with lithium-induced hyperparathyroidism (lih) is a common, but easily overlooked, complication of lithium treatment.
PubMedID- 24072092 Maternal hypercalcemia due to hyperparathyroidism causes increased transfer of ca to the fetus.
PubMedID- 23581265 In infancy, hypercalcemia generally occurs due to hyperparathyroidism, familial hypocalciuric hypercalcemia, subcutaneous fat necrosis, total parenteral nutrition administration, hyperthyroidism, and adrenal insufficiency.
PubMedID- 22620673 In the neonatal period, homozygous inactivating mutations result in neonatal severe hyperparathyroidism (nshpt) with severe symptomatic hypercalcemia, undermineralized bones, rib cage deformity, and long-bone and rib fractures [3].
PubMedID- 21391355 [primary hyperparathyroidism as a cause of hypercalcemia in a patient with breast cancer].
PubMedID- 24959180 Cinacalcet (sensipar), a calcimimetic drug, is available for the treatment of secondary hyperparathyroidism associated with renal failure, hypercalcemia in parathyroid cancer, and the treatment of severe hypercalcemia in patients with primary hyperparathyroidism unable to undergo parathyroidectomy [17–19].
PubMedID- 20510722 hypercalcemia associated with primary hyperparathyroidism has frequently resulted in the development of pancreatitis and peptic ulcer disease; however, the pathophysiologic mechanism of this association remains uncertain.
PubMedID- 24241361 Post-transplant hypercalcemia due to persistent secondary hyperparathyroidism (hpt) has a high prevalence in the first 3 months after surgery and decreases during the first year, but it persists over time in around 5-10% of renal transplant patients.
PubMedID- 21660912 Hypocalcemia, frequently seen in the setting of chronic renal insufficiency, results in prolonged st segment and qt interval while hypercalcemia, usually seen with hyperparathyroidism, results in shortening of both intervals.
PubMedID- 22840059 Today, primary hyperparathyroidism usually presents with mild hypercalcemia (within 1 mg/dl above the upper limit of normal), is usually asymptomatic, and diagnosed incidentally on routine investigations for minor non-specific complains.
PubMedID- 23225300 Introduction: hyperparathyroidism often presents with asymptomatic hypercalcemia or minimal, unspecific symptoms and the middle-age female is the predominant population.
PubMedID- 20582171 [10–1157–60] metastatic pulmonary calcification has also been reported in a patient with hypercalcemia due to hyperparathyroidism who recovered from pneumonia with sepsis and whose hrct images demonstrated localized parenchymal airspace calcification that was limited to the lower lobes[61] [figure 26].
PubMedID- 24736147 A 28 year-old girl admitted for a bone tumor of the knee, the blood test shows hypercalcemia with hyperparathyroidism, bone biopsy revealed giant cell lesions characteristic of brown tumors.
PubMedID- 23232684 A very rare type of primary hyperparathyroidism with severe hypercalcemia in an infant.
PubMedID- 24033403 Background: after renal transplantation (rtx), hypercalcemia, mainly due to persistent hyperparathyroidism, and hypophosphatemia, caused by the improved ability to excrete phosphorus in the renal tubules, are expected.

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