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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hyperaldosteronism
Comorbidity C0020538|hypertension
Sentences 24
PubMedID- 23479921 The patient had hypertension associated with hyperaldosteronism and chronic interstitial nephritis.
PubMedID- 21822477 They point out that the incidence of primary aldosteronism in patients with drug resistant hypertension is 14% to 23%, which is much higher than in the general hypertensive population.
PubMedID- 24831672 We therefore developed a nomogram to predict hypertension cure in patients with primary aldosteronism after laparoscopic adrenalectomy.
PubMedID- 26074961 hypertension due to primary aldosteronism had long been considered a form of disease associated with a relatively low incidence of cardiovascular and renal complications [6, 7].
PubMedID- 22311906 Chronic aldosterone administration increases glomerular filtration rate, whereas inhibition of mineralocorticoid receptors (mrs) markedly attenuates glomerular hyperfiltration and hypertension associated with primary aldosteronism or obesity.
PubMedID- 26574803 Primary aldosteronism is the cause of hypertension in 5-10% of the hypertensive population.
PubMedID- 25546991 [difficulty in diagnosis of primary hyperaldosteronism as the cause of resistant hypertension and severe hypokalemia--case report].
PubMedID- 23102075 The main determinants of surgical cure or control of hypertension in patients with primary hyperaldosteronism were duration of hypertension, number of antihypertensive medications, preoperative response to spironolactone, the presence of adenoma, and cyp11b2 (344 c/t) genotype.
PubMedID- 20508722 Furthermore we showed that hemin improved insulin-signaling/glucose metabolism in deoxycorticosterone-acetate (doca) hypertension, a model of primary aldosteronism [48], suggesting a role of the ho system against dysfunctional glucose metabolism in aldosteronism.
PubMedID- 21234416 Particularly in patients with resistant hypertension, the prevalence of primary aldosteronism has been found between 10% and 20% [3, 39, 40].
PubMedID- 24133375 While the finding of primary aldosteronism in patients with resistant hypertension is in the order of 20%, such patients respond to mr antagonists no differently from the remainder without elevated aldosterone levels, suggesting that mr activation may be equally important in patients with and without an established diagnosis of primary aldosterone.
PubMedID- 21042587 Owing to the absence of elevated aldosterone and doc levels, increased cortisol levels induce illicit occupation and activation of the unprotected mr leading to an apparent mineralocorticoid excess with hypertension and hypokalemia.
PubMedID- 25201428 A case of iatrogenic cushing syndrome and apparent mineralocorticoid excess presenting with accelerated hypertension and proteinuria.
PubMedID- 23153688 We suspected the presence of hyperaldosteronism because of resistant hypertension (33.1%), hypokalemia (38.2%), and hypertensive crises (12.7%).
PubMedID- 24006040 Prevalence of and risk factors for primary aldosteronism among patients with resistant hypertension in china.
PubMedID- 22547442 hyperaldosteronism combined with hypertension favored the macrophage infiltration (cd68(+) cells) in heart, and enhanced the mrna level of monocyte chemoattractant protein 1, osteopontin, and galectin 3.
PubMedID- 20119882 Primary aldosteronism is the most common form of secondary hypertension and patients with hyperaldosteronism are more prone to premature cardiovascular complications compared to essential hypertensives.
PubMedID- 21902953 Two years later, the patient developed signs of recurrent hyperaldosteronism with hypertension refractory to antihypertensive medication, hypokalemia as well as elevated aldosterone level and suppressed serum renin.
PubMedID- 21785705 [70] found a higher incidence of metabolic syndrome in primary hyperaldosteronism compared with essential hypertension patients.
PubMedID- 25016402 These compounds are used commonly in the treatment of hypertension, with or without aldosteronism, and in the volume-overload periods of various forms of heart failure, cirrhosis, and renal failure.
PubMedID- 26273475 We describe a young male patient with longstanding hypertension, who was diagnosed with primary hyperaldosteronism and treated by an attempted retroperitoneoscopic total unilateral adrenalectomy for a left-sided presumed aldosterone-secreting adenoma.
PubMedID- 25907736 We performed exome sequencing of 40 unrelated subjects with hypertension due to primary aldosteronism by age 10.
PubMedID- 24864141 Primary aldosteronism represents major cause of secondary hypertension, strongly associated with high cardiovascular morbidity and mortality.
PubMedID- 24285684 Context: the molecular mechanisms of primary aldosteronism, a common cause of human hypertension, are unknown, but alterations of k(+) channels can play a key role.

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