eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | histidinemia |
| Comorbidity | C0029442|osteomalacia |
| Sentences | 1 |
| PubMedID- 24353618 | The typical clinical manifestations of vitamin d deficiency include nonspecific backache, bone pain, and generalized body ache.7 progressive proximal muscle weakness, gait disturbances, carpopedal spasm, and bone deformity are atypical manifestations of this deficiency.8 as patients with osteomalacia might have severe neurological presentations even in cases of mild vitamin d deficiency and bone profile, it is important to conduct an observational study in clinical practice in order to assess the association between vitamin d levels and disease presentation, especially for atypical neurological and rheumatological presentations.9 thus, the objective of this study was to investigate the correlation between the neurological and rheumatological manifestations of vitamin d deficiency and the levels of 25-hydroxyvitamin [25(oh) d] and bone profile (calcium, phosphate, magnesium and alkaline phosphatase). |
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