eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hemosiderosis |
| Comorbidity | C0002871|anemia |
| Sentences | 3 |
| PubMedID- 22048530 | The blood transfusion given to correct anemia leads to hemosiderosis and the consequent complications of organ damage, with death in the second or third decade due to cardiac hemosiderosis. |
| PubMedID- 21623097 | Refractory anemia leading to renal hemosiderosis and renal failure. |
| PubMedID- 25745550 | Iron overload is usually associated with regular blood transfusions that lead to transfusional haemosiderosis in patients with chronic anemia in children with btm.23 these changes occur initially in reticulo-endothelial system and secondary in all parenchymal organs, mainly heart, pancreas, pituitary gland, and gonads, with cytotoxic effects.24 so, accumulation of iron has been implicated as a risk of cardiovascular disease, because of the catalytic role of iron, causing oxidative stresses on the vessel wall.25–27 we also found that cimt was significantly different in children with btm in relation to features suggestive of iron overload including duration since first blood transfusion which carries the highest risk factor of increasing cimt, frequency of blood transfusion, irregular use of iron chelating agents in patients who were poorly chelating or had splenectomy. |
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