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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease hemophilia
Comorbidity C0040053|thrombosis
Sentences 8
PubMedID- 21127694 Conclusion: according to our case we consider the false clinical picture of 'tense ascites' of our patient as a rare clinical presentation of decompensated liver cirrhosis, with severe edema of mesenterium and viscus, on the grounds of preexisting portal vein thrombosis, in a patient with combined hemophilia a and thrombophilia v leiden.
PubMedID- 22507808 thrombosis in hemophilia patients has a multifactorial pathogenesis and the main conditions associated with this complication are the use of long-term central venous catheters, intensive replacement therapy usually in the setting of surgical procedures, the use of bypassing agents or the coexistence of acquired or inherited prothrombotic risk factors.
PubMedID- 19412729 Several reports have dealt with the occurrence of both arterial and venous thrombosis in patients with haemophilia a, haemophilia b, and von willebrand disease.
PubMedID- 23681676 The ratio of arterial versus venous thrombosis in hemophilia a is 3.72 whereas that for hemophilia b is 1.12.
PubMedID- 23026653 It is important for the future to establish risk assessment tools that can help to determine the most effective and safe practice to prevent venous thrombosis in patients with hemophilia and other bleeding disorders who undergo surgical procedures.
PubMedID- 21088757 Bovenzi et al.11) reported a case of acute stent thrombosis in a patient with hemophilia b after coronary stent implantation who was not treated with aspirin or clopidogrel.
PubMedID- 25708424 However, a retrospective study reported subclinical deep venous thrombosis (dvt) in 10% of patients with haemophilia undergoing major orthopaedic surgery.
PubMedID- 24244342 Activated pccs have already shown an enhanced risk of thrombosis when used in patients with hemophilia [41] and this risk would be expected to increase if applied to patients with an underlying prothrombotic condition.

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