eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hemolytic anemia |
| Comorbidity | C0282193|iron overload |
| Sentences | 2 |
| PubMedID- 26550015 | The gene abnormality results in the tendency of sickle haemoglobin (hbs) when deoxygenated, to polymerize intracellularly and deform red blood cells into a characteristic sickled shape, thereby producing the clinical manifestation of a chronic haemolytic anaemia with potential iron overload. |
| PubMedID- 21644200 | Diagnostic imaging may help the clinician to identify specific complications related to either the disease (e.g., bone infarction and acute osteomyelitis in sickle cell disease) or transfusion (e.g., iron overload due to increased hemolysis) and iron chelation (e.g., desferrioxamine-related dysplastic bone changes and deferiprone-related degenerative arthritis) treatments. |
Page: 1