eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hemochromatosis |
| Comorbidity | C0011847|diabetes |
| Sentences | 5 |
| PubMedID- 20854668 | Iron overload form hereditary hemochromatosis is associated with diabetes and impaired glucose tolerance and decreased insulin secretory capacity, which is reportedly reversed with phlebotomy therapy [42,43]. |
| PubMedID- 20847537 | Excessive iron storage sometimes causes diabetes in patients with hemochromatosis, a disease caused by iron overloading. |
| PubMedID- 23599042 | The prevalence of type 2 diabetes in patients with hereditary hemochromatosis and iron-loading thalassemia supports this hypothesis. |
| PubMedID- 22284844 | Hypogonadotropic hypogonadism is frequent in haemochromatosis (often associated with diabetes), whereas primary hypogonadism is reported in alstrom disease and cystinosis (both associated with diabetes, the latter also with thyroid dysfunction) and galactosemia. |
| PubMedID- 21781351 | For further description see table 1. patients having diabetes as a consequence of known chronic pancreatitis, haemochromatosis, mutations in the insulin receptor, lipodystrophy, maturity-onset diabetes of the young, maternally inherited diabetes and deafness, family history of first-degree relatives with type 1 diabetes, insulin requirement within the first year after diabetes diagnosis or a fasting serum c-peptide level ≤ 150 pmol/l at time of recruitment were excluded from the category of clinically defined t2dm. |
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