eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | hartnup disease |
| Comorbidity | C0025202|melanoma |
| Sentences | 8 |
| PubMedID- 25860257 | The expression of mcl-1 is also known to increase in melanoma with disease progression [50]. |
| PubMedID- 25933140 | We here present the first case, to our knowledge, of diffuse nonnecrotizing granulomatous lymphadenopathy occurring simultaneously with disease progression in a patient with metastatic melanoma after receiving the second dose of ipilimumab. |
| PubMedID- 24212610 | Cxcr4 expression in primary melanoma is associated with disease progression [157]. |
| PubMedID- 25749524 | For the pilot study, plasma samples were obtained from six healthy donors and ajcc stage iii (n = 20) and iv (n = 26) melanoma patients with disease present. |
| PubMedID- 22973551 | In a recent case report published in the new england journal of medicine, a patient suffering from metastatic melanoma with disease progression on ipilimumab (ipi, yervoy; bristol-myers squibb), a mab that inhibits ctl-associated antigen 4 (ctla-4), an immunologic checkpoint on t cells, showed a favorable response only after receiving local rt for a metastatic spinal lesion (postow et al., 2012). |
| PubMedID- 25687848 | There is no standard second-line regimen for malignant melanoma patients with disease progression after first-line chemotherapy, even though progression-free survival (pfs) is short in malignant melanoma. |
| PubMedID- 21211030 | While these authors demonstrated that ski and snon expression in melanoma is not associated with disease progression, they extrapolated, without experimental evidence, that ski and snon may mediate the resistance of melanomas to growth inhibition by tgf-β. |
| PubMedID- 21619542 | melanoma produces increasing amounts of tgf-beta with disease progression, inhibiting immune responses and providing an optimal microenvironment for undisturbed tumor growth. |
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