eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | glutaryl-coa dehydrogenase deficiency |
| Comorbidity | C0041296|tuberculosis |
| Sentences | 1 |
| PubMedID- 23076359 | In m. tuberculosis, overexpression of siga improves the bacterial replication in mononuclear phagocytes and in c57bl/6 mice compared with control strain.390 knockdown of siga in two m. tuberculosis strains negatively affected the bacterial replication inside a human macrophage cell line and in lungs of c57bl/6 mice, and elicited a minimal local inflammatory response.390 moreover, it has been reported that siga interacts with whib3, a putative transcription regulator and that the inactivation of whib3 conferred an attenuated phenotype to a wild-type m. bovis, thus, suggesting that the siga-whib3 interaction was the cause of the observed attenuation.393 however, inactivation of whib3 in m. tuberculosis resulted in partial attenuation of its virulence,393 implying that the genetic background may define the relevance of particular genes in the virulence of pathoghenic mycobacteria. |
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