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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease giant cell tumor of bone
Comorbidity C0017525|giant cell tumor
Sentences 10
PubMedID- 26225290 The radiologic investigations and biopsy result indicated a giant cell tumor of the bone.
PubMedID- 26587204 Chondrosarcoma, osteoblastoma, aneurysmal bone cyst, giant cell tumor of the bone, metastasis, multiple myeloma, and collapsed hemangioma of the vertebral bodies are the most common differential diagnoses in radiological investigations.
PubMedID- 24326015 Approved monoclonal antibodies by the fda in 2013 include ado-trastuzumab emtansine and pertuzumab for her2+ breast cancer, denosumab for giant cell tumor of the bone, bevacizumab for both first and second line therapy for metastatic colorectal cancer in combination with chemotherapy.
PubMedID- 24251081 Denosumab binds to tumor necrosis factor (ligand) superfamily, member 11 (tnfsf11, best known as rankl),32 a transmembrane and soluble protein produced by osteoblasts and giant cell tumor of the bone (gctb) cells that activates osteoclasts, the cells involved in bone resorption.
PubMedID- 20976205 Despite the morphologic similarities between giant cell tumor of bone (primary osteoclastoma) and orucub, both lesions show differences in various critical aspects.
PubMedID- 22464651 giant cell tumor of the bone may mimic chondroblastoma, as the epiphyseal location can be quite similar.
PubMedID- 21375769 Histologic diagnosis was giant cell tumor of the bone.
PubMedID- 20806072 [16] in a solitary lytic bone lesion as seen in our case, giant cell tumor of the bone or osteosarcoma has to be considered in the differential diagnosis.
PubMedID- 21660263 For this particular systematic review, all available human clinical studies were included, except for studies in rheumatoid arthritis and giant cell tumor of the bone.
PubMedID- 24891890 True neoplastic lesions such as giant cell tumor of the bone may have very similar findings as bt.

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