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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease fibromyalgia
Comorbidity C0029408|osteoarthritis
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PubMedID- 24379695 Clbp is considered a mixed-pain syndrome, with the potential for multifactorial etiology and pain mechanisms, including nociceptive, neuropathic, and hyperalgesic components.35,36 duloxetine is believed to act upon descending inhibitory pain pathways,37 and has demonstrated efficacy in a variety of other chronic pain conditions, including dpnp,38,39 fibromyalgia,40,41 and pain associated with osteoarthritis of the knee.42 future studies, such as long-term pragmatic clinical trials or patient survey, physician survey, or chart review that collect data on effectiveness of treatment and reasons for treatment discontinuation or switch, are needed to confirm the drivers of treatment outcomes in clbp, including better compliance.
PubMedID- 20662040 Adjusted for age and sex, the hazard ratio for fibromyalgia compared with osteoarthritis was 1.05 (95% ci 0.94-1.17).

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