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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease eosinophilia
Comorbidity C0004096|asthma
Sentences 20
PubMedID- 21625544 Allergic asthma is associated with airway eosinophilia, which is regulated by different t-effector cells.
PubMedID- 22419386 asthma was not associated with high tissue eosinophilia (p = 0.60), with 43% of nonasthmatics demonstrating high tissue eosinophilia.
PubMedID- 25981191 Methods: we conducted a randomized, double-blind, placebo-controlled, multicenter clinical trial of sb010 involving patients who had allergic asthma with sputum eosinophilia and who also had biphasic early and late asthmatic responses after laboratory-based allergen provocation.
PubMedID- 22921086 asthma is sever, associated with eosinophilia and extrapulmonary symptoms.
PubMedID- 21505837 [19-year-old asthma patient with pronounced eosinophilia and acute coronary syndrome].
PubMedID- 23253516 Atopic asthma was associated with eosinophilia and non-atopic asthma was associated with ifn-gamma and elevated monocytes in blood.
PubMedID- 22541618 In patients with severe, refractory asthma associated with eosinophilia, however, clinical trials have demonstrated significant reductions in asthma exacerbations.
PubMedID- 22880030 An ovine orthologue, galectin-14, has been shown to be secreted in the airway mucus of a sheep asthma model closely associated with lung eosinophilia [18], [25].
PubMedID- 23593249 Beta5i-deficient mice showed reduced ova/alum- and subcutaneous/ova-induced acute asthma with decreased eosinophilia in the bronchoalveolar lavage (bal), low ova-specific igg1 and reduced local and systemic th2 cytokines.
PubMedID- 23134444 By logistic regression analysis, allergic asthma, presence of peripheral eosinophilia and use of inhaled steroids remained significant.
PubMedID- 24991461 Moreover, anti-ige therapy exerts profound and significant reductions in airway and tissue eosinophilia in patients with mild allergic asthma and on allergen-induced seasonal increases in circulating and tissue eosinophils in subjects with allergic rhinitis.28 these findings suggest that anti-ige therapy can be considered a steroid-sparing option for eae.
PubMedID- 22187177 The presence of asthma, sinusitis associated with peripheral eosinophilia and organ symptoms suggesting a vasculitis could support the diagnosis, without histologic evidence.
PubMedID- 26194544 Conclusions: our findings suggest that ilc2s can promote the persistence of airway eosinophilia in patients with severe asthma through uncontrolled localized production of the type 2 cytokines il-5 and il-13, despite high-dose oral corticosteroid therapy.
PubMedID- 25801413 Their use as a single surrogate marker for airway eosinophilia in patients with asthma will lead to a substantial number of false positives or false negatives.
PubMedID- 24846699 high blood eosinophil count is associated with more frequent asthma attacks in asthma patients.
PubMedID- 24530234 asthma is severe, associated with eosinophilia and extrapulmonary symptoms.
PubMedID- 26502193 Hmabs targeting il-5 have shown great promise in severe refractory asthma with a persisting eosinophilia, and clinical trials with hmabs against il-13 and il4ralpha have also shown clinical benefit.
PubMedID- 21320344 Total serum ige, atopy, testing positive for food allergens, and eosinophilia were significantly associated with asthma (table 1) and evaluated as outcomes in separate statistical models.
PubMedID- 25936567 This suggests that ccl26 production by becs might be involved in persistent eosinophilia in patients with severe asthma despite treatment with high corticosteroid doses.
PubMedID- 23592945 Churg-strauss syndrome was diagnosed based on the patient's history of asthma, sinusitis, eosinophilia, nasal polyps, transient radiological pulmonary infiltrations and transient paresthesia over the left tibia, and eosinophilic pericardial effusion and eosinophilic infiltrations revealed in a myocardial biopsy.

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