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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease down syndrome
Comorbidity C0497327|dementia
Sentences 22
PubMedID- 23400708 Apoe4 is a major genetic risk factor for alzheimer disease and is associated with dementia in down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders.
PubMedID- 24885175 Interestingly, down syndrome patients with ad dementia also have an increase in mtdna mutations[9].
PubMedID- 26483832 Cognitive rehabilitation of dementia in adults with down syndrome: a review of non-pharmacological interventions.
PubMedID- 23902161 Conclusion: the previously reported high risk levels for dementia among people with down syndrome was confirmed in these data as was the value of the instruments utilised in tracking decline and helping to confirm diagnosis even in persons with severe intellectual disability.
PubMedID- 21542885 The clinical and scientific study of dementia in adults with down syndrome led to the development of the amyloid hypothesis as a fundamental concept in alzheimer's disease pathogenesis.
PubMedID- 23601808 Evidence that picalm affects age at onset of alzheimer's dementia in down syndrome.
PubMedID- 25720405 Our findings suggest the potential value of this gene as a blood marker of early dementia in individuals with down syndrome.
PubMedID- 25735452 down syndrome (ds) patients with early-onset dementia share similar neurodegenerative features with alzheimer's disease (ad).
PubMedID- 20597723 Improvements in understanding the progression of dementia in individuals with down syndrome may lead to improved diagnosis and treatment.
PubMedID- 21041786 Change in plasma ass peptides and onset of dementia in adults with down syndrome.
PubMedID- 20367747 Background: the latter stages of dementia in individuals with down syndrome are well documented; however, earlier cognitive and behavioural changes have only recently been described.
PubMedID- 25363568 The presentation of dementia in down syndrome differs compared with typical alzheimer's disease.
PubMedID- 23962297 dementia in down's syndrome: an mri comparison with alzheimer's disease in the general population.
PubMedID- 21739598 There is a paucity of treatment trials for dementia in down syndrome in comparison to alzheimer disease in the general (non-down syndrome) population.
PubMedID- 24406638 Recent research has tended to focus on dementia in down syndrome.
PubMedID- 25551263 Variability of the aging process in dementia-free adults with down syndrome.
PubMedID- 20494326 Early-onset dementia in adults with down's syndrome does not seem to be associated with atherosclerotic complications.
PubMedID- 22888254 down syndrome patients with dementia also show loss of memory, cognitive decline, changes in adaptive behavior, neurological changes, and language difficulties;25,26 these symptoms are progressive (not reversible).27 in contrast, the clinical features of individuals with acute neuropsychiatric disorders appear to be more similar to those of individuals with psychiatric illnesses, such as major depressive and obsessive-compulsive disorder or schizophrenia (table 1).
PubMedID- 22935789 A public-private partnership to establish biomarkers of dementia in down's syndrome could aid the development of preventive therapies for the dementia associated with both down's syndrome and alzheimer's disease, based on the apparent common pathogenic role of amyloid precursor protein in the two conditions.
PubMedID- 26343344 Behavioural and psychological symptoms of dementia in down syndrome: early indicators of clinical alzheimer's disease.
PubMedID- 26295718 Care considerations for dementia in people with down's syndrome: a management perspective.
PubMedID- 26107323 Diagnosing dementia in adults with down's syndrome.

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