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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease down syndrome
Comorbidity C0025362|mental retardation
Sentences 10
PubMedID- 20084109 Previous studies have shown that folate deficiency may contribute to mental retardation in down's syndrome (ds).
PubMedID- 21909210 He also suffered mental retardation due to down syndrome since birth.
PubMedID- 24014994 She was a known case of down's syndrome with mental retardation and delayed developmental milestones with no family history of similar complaints.
PubMedID- 21607765 We report the clinical management of 2 adults with mental retardation because of trisomy 21 who were sedated with high-dose dexmedetomidine (dex) alone during diagnostic cardiac catheterization (dcc).
PubMedID- 22765017 Dual-specificity tyrosine(y)-phosphorylation-regulated kinase 1a (dyrk1a) is a protein kinase that might be responsible for mental retardation and early onset of alzheimer's disease in down's syndrome patients.
PubMedID- 24396504 down's syndrome is associated with mental retardation and delay in physical growth.
PubMedID- 20528079 In addition to mental retardation, individuals with down syndrome (ds) also develop the neuropathological changes typical of alzheimer's disease (ad) and the majority of these individuals exhibit dementia.
PubMedID- 22115353 However, excessive production of hydrogen sulfide, by using inorganic hydrogen sulfide donors such as nahs, may contribute to the pathogenesis of inflammatory diseases, septic shock, cerebral stroke and mental retardation in patients with down syndrome.
PubMedID- 24760020 In down's syndrome (trisomy 21), the prevailing cause of mental retardation, there is upregulation of the pluripotent neuroinflammatory cytokine il-1, which can be brought about by changes occurring as a result of chromosome 21 gene products [56].
PubMedID- 21266456 mental retardation in down syndrome (ds) appears to be related to severe neurogenesis impairment during critical phases of brain development.

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