eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | down syndrome |
| Comorbidity | C0023449|acute lymphoblastic leukemia |
| Sentences | 4 |
| PubMedID- 20418240 | Methotrexate clearance was 5% lower in the acute lymphoblastic leukemia patients with down syndrome (p=0.001); however, this small difference is probably clinically not relevant, because no significant differences in methotrexate plasma levels were detected at 24 and 48 hours. |
| PubMedID- 22072402 | Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with down syndrome (ml-ds and ds-all) have revealed significant differences in abnormality patterns between such cases and acute leukemias in general. |
| PubMedID- 24222333 | acute lymphoblastic leukemia in children with down syndrome: a retrospective analysis from the ponte di legno study group. |
| PubMedID- 24391118 | Outcome of transplantation for acute lymphoblastic leukemia in children with down syndrome. |
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